| Literature DB >> 26690969 |
Boris Virine, Carla Osiowy, Shan Gao, Tong Wang, Eliana Castillo, Steven R Martin, Samuel S Lee, Kimberley Simmonds, Guido van Marle, Carla S Coffin.
Abstract
Entities:
Year: 2015 PMID: 26690969 PMCID: PMC4686842 DOI: 10.1371/journal.pone.0145898
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 1Neighbor-joining phylogenetic reconstruction of the HBV pre-S/S (A, N = 20), Pre-C/C (B, N = 11) and full genome (C, N = 3) using the bootstrap method.
Clustering is prominent between individual cases, indicating a greater degree of variation between individuals, than amongst each of their viral quasispecies. Bootstrap values greater than 70 were considered significant. Case #146 was excluded from analysis as only the pre-S1 region was sequenced.
Fig 2Comparison of distance amongst HBV quasispecies in patients during pregnancy and post-partum in pre-S/S (A, N = 5) and pre-C/C (B, N = 5) region.
Measurement of distance within patient samples is shown and compared to measurement of distance within patient samples categorized by genotype. A comparison of relative evolutionary distances of patient samples collected at different time points is shown. Measurement of HBV distance within each individual sample is shown and compared to measurement of distance within individuals categorized by genotype. A comparison of relative evolutionary distances of HBV in each sample collected at different time points is shown.