Itziar Casado1, Angela Domínguez2,3, Diana Toledo3, Judith Chamorro4, Lluis Force5, Núria Soldevila2,3, Jenaro Astray6, Mikel Egurrola7, Pere Godoy2,8,9, José M Mayoral10, Sonia Tamames11, Francisco Sanz12, Jesús Castilla1,2. 1. a Instituto de Salud Pública de Navarra , IdiSNA - Navarra Institute for Health Research , Pamplona , Spain. 2. b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain. 3. c Departament de Salut Pública , Universitat de Barcelona , Barcelona , Spain. 4. d Servicio de Medicina Preventiva, Complejo Hospitalario de Navarra , Pamplona , Spain. 5. e Unidad de Enfermedades Infecciosas, Hospital de Mataró , Mataró , Spain. 6. f Dirección de Salud Pública, Consejería de Sanidad , Madrid , Spain. 7. g Servicio de Neumología, Hospital de Galdakao , Usansolo , Spain. 8. h Agència de Salut Pública de Catalunya , Barcelona , Spain. 9. i Institut de Recerca Biomèdica de Lleida , Universitat de Lleida , Lleida , Spain. 10. j Servicio de Vigilancia, Junta de Andalucía , Sevilla , Spain. 11. k Dirección General de Salud Pública, Investigación, Desarrollo e Innovación , Valladolid , Spain. 12. l Servicio de Neumología, Consorci Hospital General Universitari de Valencia , Valencia , Spain.
Abstract
OBJECTIVES: This study aimed to assess whether influenza vaccination reduces the risk of severe and fatal outcomes in influenza inpatients aged ≥65 years. METHODS: During the 2013-2014 influenza season persons aged ≥65 years hospitalized with laboratory-confirmed influenza were selected in 19 Spanish hospitals. A severe influenza case was defined as admission to the intensive care unit, death in hospital or within 30 days after admission. Logistic regression was used to compare the influenza vaccination status between severe and non-severe influenza inpatients. RESULTS: Of 433 influenza confirmed patients, 81 (19%) were severe cases. Vaccination reduced the risk of severe illness (odds ratio: 0.57; 95%CI: 0.33-0.98). The cumulative number of influenza vaccine doses received since the 2010-2011 season was associated with a lower risk of severe influenza (odds ratio: 0.78; 95% CI 0.66-0.91). CONCLUSION: Adherence to seasonal influenza vaccination in the elderly may reduce the risk of severe influenza outcomes.
OBJECTIVES: This study aimed to assess whether influenza vaccination reduces the risk of severe and fatal outcomes in influenza inpatients aged ≥65 years. METHODS: During the 2013-2014 influenza season persons aged ≥65 years hospitalized with laboratory-confirmed influenza were selected in 19 Spanish hospitals. A severe influenza case was defined as admission to the intensive care unit, death in hospital or within 30 days after admission. Logistic regression was used to compare the influenza vaccination status between severe and non-severe influenza inpatients. RESULTS: Of 433 influenza confirmed patients, 81 (19%) were severe cases. Vaccination reduced the risk of severe illness (odds ratio: 0.57; 95%CI: 0.33-0.98). The cumulative number of influenza vaccine doses received since the 2010-2011 season was associated with a lower risk of severe influenza (odds ratio: 0.78; 95% CI 0.66-0.91). CONCLUSION: Adherence to seasonal influenza vaccination in the elderly may reduce the risk of severe influenza outcomes.
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