Mandana Izadpanah1, Hossein Khalili1, Mostafa Mohammadi2. 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Anesthesiology & Critical Care Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
AIM: In this study, safety of two methods of unfractionated heparin administration for venous thromboembolism prophylaxis was compared in critically ill surgical patients. METHODS: A total of 50 surgical critically ill patients randomly assigned to either subcutaneous unfractionated heparin 5000 units three-times a day or continuous intravenous infusion; 625 IU/h. During the intensive care unit (ICU) stay, patients' hemodynamic parameters, laboratory tests, symptoms and signs of thrombosis and bleeding were monitored closely. RESULTS: During the patients' follow-up, no episode of bleeding or venous thromboembolism event was recorded. The differences in ICU and hospital stays were not significantly different between the groups. CONCLUSION: There are limited evidences regarding safety and efficacy of continuous intravenous infusion of unfractionated heparin for thromboprophylaxis.
RCT Entities:
AIM: In this study, safety of two methods of unfractionated heparin administration for venous thromboembolism prophylaxis was compared in critically ill surgical patients. METHODS: A total of 50 surgical critically ill patients randomly assigned to either subcutaneous unfractionated heparin 5000 units three-times a day or continuous intravenous infusion; 625 IU/h. During the intensive care unit (ICU) stay, patients' hemodynamic parameters, laboratory tests, symptoms and signs of thrombosis and bleeding were monitored closely. RESULTS: During the patients' follow-up, no episode of bleeding or venous thromboembolism event was recorded. The differences in ICU and hospital stays were not significantly different between the groups. CONCLUSION: There are limited evidences regarding safety and efficacy of continuous intravenous infusion of unfractionated heparin for thromboprophylaxis.
Authors: Alexandria J Robbins; Mariya E Skube; Melena D Bellin; Ty B Dunn; Scott A Chapman; K Louise Berry; Elizabeth Lusczek; Gregory J Beilman Journal: Pancreas Date: 2019 Nov/Dec Impact factor: 3.327