Jonathan Paraskos1, Zsofia Berke2, Jason Cook2, Jeffrey N Miner3, Martin Braddock1, Adam Platt4, Glen Hughes1. 1. a Research & Development , AstraZeneca , Macclesfield , UK. 2. b Research & Development , AstraZeneca , Mölndal , Sweden. 3. c Research & Development , Ardea Biosciences (a member of the AstraZeneca Group) , San Diego , California , USA. 4. d Companion Diagnostics , AstraZeneca , Cambridge , UK.
Abstract
OBJECTIVE: A key goal in gout treatment is achieving sustained serum uric acid (sUA) lowering. Point-of-care test (PoCT) meters provide convenient, rapid measures of sUA levels to monitor/adjust therapy. Four commercially available sUA PoCT meters were compared qualitatively (ease of use) and quantitatively (precision/accuracy). METHODS: Liquid chromatography mass spectrometry (LC-MS) analysis was used as a laboratory reference method to compare precision of PoCT devices using blood samples from 20 healthy volunteers. Accuracy was compared against the LC-MS reference method and a laboratory clinical chemistry platform. RESULTS: Qualitatively, EasyTouch(®) GU and UASure were least user-friendly, requiring repeated attempts for accurate use. HumaSens and BeneCheck provided good usability and assay precision. Cross-validation of meter precision with laboratory-based uricase assay gave good correlations between both methods (R(2) = 0.8061 and 0.7605, respectively). CONCLUSION: UA PoCT meters can be important in managing gout, and the characteristics compared herein may enhance successful patient uptake.
OBJECTIVE: A key goal in gout treatment is achieving sustained serum uric acid (sUA) lowering. Point-of-care test (PoCT) meters provide convenient, rapid measures of sUA levels to monitor/adjust therapy. Four commercially available sUA PoCT meters were compared qualitatively (ease of use) and quantitatively (precision/accuracy). METHODS: Liquid chromatography mass spectrometry (LC-MS) analysis was used as a laboratory reference method to compare precision of PoCT devices using blood samples from 20 healthy volunteers. Accuracy was compared against the LC-MS reference method and a laboratory clinical chemistry platform. RESULTS: Qualitatively, EasyTouch(®) GU and UASure were least user-friendly, requiring repeated attempts for accurate use. HumaSens and BeneCheck provided good usability and assay precision. Cross-validation of meter precision with laboratory-based uricase assay gave good correlations between both methods (R(2) = 0.8061 and 0.7605, respectively). CONCLUSION: UA PoCT meters can be important in managing gout, and the characteristics compared herein may enhance successful patient uptake.
Entities:
Keywords:
Uric acid; diagnostic test; gout; point-of-care systems
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