Literature DB >> 26689407

Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion.

Mohammed Maniruzzaman1, Muhammad T Islam1, Sheelagh Halsey2, Devyani Amin1, Dennis Douroumis3.   

Abstract

The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides-Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH > 5.5.

Entities:  

Keywords:  controlled release; hot melt extrusion; in-line NIR; solid dispersions

Mesh：

Substances：

Year:  2015        PMID： 26689407      PMCID： PMC4766126          DOI： 10.1208/s12249-015-0470-2

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  26 in total

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Journal:  Int J Pharm       Date:  2012-01-17       Impact factor: 5.875

Review 2.  A flexible technology for modified-release drugs: multiple-unit pellet system (MUPS).

Authors:  Shajahan Abdul; Anil V Chandewar; Sunil B Jaiswal
Journal:  J Control Release       Date:  2010-05-19       Impact factor: 9.776

Review 3.  Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes.

Authors:  T De Beer; A Burggraeve; M Fonteyne; L Saerens; J P Remon; C Vervaet
Journal:  Int J Pharm       Date:  2010-12-15       Impact factor: 5.875

Review 4.  Pharmaceutical applications of hot-melt extrusion: part I.

Authors:  Michael M Crowley; Feng Zhang; Michael A Repka; Sridhar Thumma; Sampada B Upadhye; Sunil Kumar Battu; James W McGinity; Charles Martin
Journal:  Drug Dev Ind Pharm       Date:  2007-09       Impact factor: 3.225

5.  Inline monitoring and a PAT strategy for pharmaceutical hot melt extrusion.

Authors:  Patrick R Wahl; Daniel Treffer; Stefan Mohr; Eva Roblegg; Gerold Koscher; Johannes G Khinast
Journal:  Int J Pharm       Date:  2013-07-31       Impact factor: 5.875

6.  PAT tools for the control of co-extrusion implants manufacturing process.

Authors:  Fabrice Krier; Jérôme Mantanus; Pierre-Yves Sacré; Pierre-François Chavez; Justine Thiry; Aude Pestieau; Eric Rozet; Eric Ziemons; Philippe Hubert; Brigitte Evrard
Journal:  Int J Pharm       Date:  2013-10-19       Impact factor: 5.875

7.  Dissolution behavior and gastrointestinal absorption of dicumarol from solid dispersion systems of dicumarol-polyvinylpyrrolidone and dicumarol-beta-cyclodextrin.

Authors:  H Sekikawa; N Fukuda; M Takada; K Ohtani; T Arita; M Nakano
Journal:  Chem Pharm Bull (Tokyo)       Date:  1983-04       Impact factor: 1.645

8.  Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process.

Authors:  L Saerens; L Dierickx; B Lenain; C Vervaet; J P Remon; T De Beer
Journal:  Eur J Pharm Biopharm       Date:  2010-10-07       Impact factor: 5.571

9.  A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone.

Authors:  Vincent Caron; Lidia Tajber; Owen I Corrigan; Anne Marie Healy
Journal:  Mol Pharm       Date:  2011-03-03       Impact factor: 4.939

10.  Klucel™ EF and ELF polymers for immediate-release oral dosage forms prepared by melt extrusion technology.

Authors:  Noorullah Naqvi Mohammed; Soumyajit Majumdar; Abhilasha Singh; Weibin Deng; Narasimha S Murthy; Elanor Pinto; Divya Tewari; Thomas Durig; Michael A Repka
Journal:  AAPS PharmSciTech       Date:  2012-09-08       Impact factor: 3.246
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  3 in total

1.  Pharmaceutical Thermal Processing.

Authors:  Feng Zhang; Michael A Repka
Journal:  AAPS PharmSciTech       Date:  2016-02-09       Impact factor: 3.246

2.  Formulation and Characterization of Acetazolamide/Carvedilol Niosomal Gel for Glaucoma Treatment: In Vitro, and In Vivo Study.

Authors:  Rehab Abdelmonem; Sammar F Elhabal; Nevine S Abdelmalak; Mohamed A El-Nabarawi; Mahmoud H Teaima
Journal:  Pharmaceutics       Date:  2021-02-05       Impact factor: 6.321

3.  Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of Vildagliptin: In Vitro and In Vivo Studies.

Authors:  Khaled H Al Zahabi; Hind Ben Tkhayat; Ehab Abu-Basha; Al Sayed Sallam; Husam M Younes
Journal:  Pharmaceutics       Date:  2021-12-15       Impact factor: 6.321
  3 in total

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