Gabriela Egaña-Ugrinovic1, Anna Goncé1, Laura García1, Maria-Angeles Marcos2, Marta López1, Alfons Nadal3, Francesc Figueras1. 1. a BCNatal-Barcelona Center of Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan De Deu), IDIBAPS, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER-ER) , Barcelona , Spain . 2. b Microbiology Service, Biomedical Diagnosis Centre. Hospital Clínic-IDIBAPS, University of Barcelona , Barcelona , Spain , and. 3. c Department of Pathology , Hospital Clínic-IDIBAPS, University of Barcelona , Barcelona , Spain.
Abstract
OBJECTIVE: The purpose of this study was to describe the fetal/neonatal cytomegalovirus (CMV) status according to chorionicity and outcome in twin pregnancies diagnosed with CMV. METHODS: An opportunistic diagnosis of CMV infection was performed in a tertiary referral center. All cases diagnosed in twin pregnancies (2006-2011) were included. Prenatal diagnosis was performed by CMV-DNA in the amniotic fluid (AF) of both fetuses only on the evidence of sonographic findings in either one or both twins. Neonatal screening was selectively assessed in symptomatic newborns, preterm, and infants born to HIV-infected mothers. Congenital infection was considered in the presence of CMV-DNA in AF, fetal tissues or newborn urine within the first 2 weeks of life, and symptomatic disease with clinical findings at birth or autopsy. RESULTS: A total of six twin pregnancies with congenital CMV infection were diagnosed, five dichorionic and one monochorionic diamniotic. Only one sibling was infected among dichorionic pregnancies, two diagnosed prenatally, and three after birth. In the monochorionic pregnancy, the diagnosis was performed prenatally and the two fetuses were infected and severely damaged. CONCLUSIONS: Congenital CMV infection in twins might be related, among other factors, to chorionicity, and in DC twins a non-concordant infection can be expected.
OBJECTIVE: The purpose of this study was to describe the fetal/neonatal cytomegalovirus (CMV) status according to chorionicity and outcome in twin pregnancies diagnosed with CMV. METHODS: An opportunistic diagnosis of CMV infection was performed in a tertiary referral center. All cases diagnosed in twin pregnancies (2006-2011) were included. Prenatal diagnosis was performed by CMV-DNA in the amniotic fluid (AF) of both fetuses only on the evidence of sonographic findings in either one or both twins. Neonatal screening was selectively assessed in symptomatic newborns, preterm, and infants born to HIV-infected mothers. Congenital infection was considered in the presence of CMV-DNA in AF, fetal tissues or newborn urine within the first 2 weeks of life, and symptomatic disease with clinical findings at birth or autopsy. RESULTS: A total of six twin pregnancies with congenital CMV infection were diagnosed, five dichorionic and one monochorionic diamniotic. Only one sibling was infected among dichorionic pregnancies, two diagnosed prenatally, and three after birth. In the monochorionic pregnancy, the diagnosis was performed prenatally and the two fetuses were infected and severely damaged. CONCLUSIONS:Congenital CMV infection in twins might be related, among other factors, to chorionicity, and in DC twins a non-concordant infection can be expected.
Authors: Victor S Santos; Sheila J G Oliveira; Ricardo Q Gurgel; Dorothy R R Lima; Cliomar A Dos Santos; Paulo R S Martins-Filho Journal: Am J Trop Med Hyg Date: 2017-07 Impact factor: 2.345
Authors: Nancy A Otieno; Bryan O Nyawanda; Fredrick Otiato; Martina Oneko; Minal M Amin; Michael Otieno; Daniel Omollo; Meredith McMorrow; Sandra S Chaves; Sheila C Dollard; Tatiana M Lanzieri Journal: J Clin Virol Date: 2019-09-17 Impact factor: 3.168