| Literature DB >> 26687759 |
Tianzhen Wang1, Peng Han2, Yan He1, Ci Zhao3, Guangyu Wang3, Weiwei Yang1, Ming Shan4, Yuanyuan Zhu3, Chao Yang1, Mingjiao Weng1, Di Wu5, Lin Gao6, Xiaoming Jin1, Yunwei Wei7, BinBin Cui8, Guomin Shen9, Xiaobo Li10.
Abstract
RNA-binding protein Lin28A is frequently over-expressed in human malignant tumors and is associated with tumor advance and poor prognosis. However, the expression pattern and functions of Lin28A in colon cancer are unknown. In this study, we detected the expression of Lin28A in colon cancer patients and tested the effect of Lin28A on the chemotherapeutic sensitivity of colon cancer cells to 5-fluorouracil (5-FU). As expected, we showed that Lin28A is up-regulated in 73.3 % of colon cancer patients. However, to our surprise, we found that oncogenic protein Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting the cell apoptosis. Further mechanisms study revealed that the effect of Lin28A increasing chemosensitivity of cancer cells is in a let-7 independent manner, but which is associated with decreasing the expression of DNA damage repair protein H2AX. Conclusively, here we reported an unexpected function of Lin28A, which may shed lights on fully understanding the physiological and pathological roles of this oncogene.Entities:
Keywords: Apoptosis; Chemosensitivity; Colon cancer; H2AX; Lin28A
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Year: 2015 PMID： 26687759 DOI： 10.1007/s13277-015-4559-8
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283