| Literature DB >> 26687558 |
Yi Zhang1, Xiaoxia Li2, Jingya Ruan2, Tingting Wang3, Yongzhe Dong2, Jia Hao3, Erwei Liu1, Lifeng Han1, Xiumei Gao1, Tao Wang4.
Abstract
Astragalus membranaceus is a Traditional Chinese Medicine (TCM) belonging to the Leguminosae family. It has been used as antidiabetic, cardioprotective, and hepatoprotective in the TCM clinic. From the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, 14 oleanane type saponins (1-14) including eight new ones, astroolesaponins A (1), B (2), C1 (3), C2 (4), D (5), E1 (6), E2 (7), and F (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods. Compounds 1-5, 7, 8, 11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells.Entities:
Keywords: Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao; HepG2 cells; Oleanane type; Saponin; Stem; Triglyceride accumulation inhibitory effects
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Year: 2015 PMID： 26687558 DOI： 10.1016/j.fitote.2015.12.006
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882