| Literature DB >> 26687557 |
Yi Liu1, Ming-Hua Yang2, Xiao-Bing Wang1, Tian-Xiao Li1, Ling-Yi Kong3.
Abstract
Eight new caryophyllene sesquiterpenoids named pestaloporinates A-G (1-7) and 14-acetylhumulane (8) have been isolated from the solid cultures of an endophytic fungus Pestalotiopsis sp., which was obtained from the fresh stem bark of Melia azedarach Linn. Their structures as well as absolute configurations were determined by spectroscopic data, ECD experimentation, and single-crystal X-ray diffraction. Among all the isolates, compound 2 displayed potent inhibitory activity with IC50 value of 19.0 μM during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells.Entities:
Keywords: Caryophyllene sesquiterpenoids; Ethyl ethanoate (PubChem CID: 8857); Methanol (PubChem CID: 887); Methyl cyanide (PubChem CID: 6342); Methylene chloride (PubChem CID: 6344); NO inhibition; Pestalotiopsis sp.; Pyridine (PubChem CID: 1049)
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Year: 2015 PMID： 26687557 DOI： 10.1016/j.fitote.2015.12.003
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882