Huikun Liu1, Shuang Zhang1, Leishen Wang1, Junhong Leng1, Weiqin Li1, Nan Li1, Min Li1, Yijuan Qiao1, Huiguang Tian1, Jaakko Tuomilehto2, Xilin Yang3, Zhijie Yu4, Gang Hu5. 1. Tianjin Women's and Children's Health Center, 96 Guizhou Road, Heping District, Tianjin 300070, China. 2. Department of Public Health, University of Helsinki, Helsinki, Finland; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria; Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia. 3. Department of Epidemiology and Biostatistics, Tianjin Medical University, 22 Qixiangtai Road, Heping district, Tianjin 300070, China. 4. Population Cancer Research program, Dalhousie University, 6299 South Street, Halifax, NS, Canada B3H 4R2. 5. Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address: gang.hu@pbrc.edu.
Abstract
AIMS: Very few studies have assessed the association of fasting and 2h glucose, and HbA1c during pregnancy with postpartum diabetes risk among women with prior gestational diabetes mellitus (GDM). We assessed the association of fasting glucose, 2h glucose and HbA1c at 26-30 gestational weeks with postpartum diabetes risk among women with prior GDM. METHODS: A cohort study in 1263 GDM women at 1-5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of fasting and 2h plasma glucose, and HbA1c at 26-30 gestational weeks with the risk of diabetes at postpartum. RESULTS: The multivariable-adjusted (age, pre-pregnancy body mass index, weight gain during pregnancy, current body mass index, family history of diabetes, marital status, education, family income, smoking status, passive smoking, leisure-time physical activity, alcohol drinking, and intake of energy, saturated fat, and dietary fiber) hazard ratios of postpartum diabetes were 1.61 (95% confidence interval [CI]: 1.36-1.91) for each 1 mmol/l increase in fasting glucose during pregnancy, 1.63 (95% CI: 1.45-1.84) for each 1 mmol/l increase in 2h glucose during pregnancy, 2.11 (95% CI: 1.50-2.97) for each 1 unit (%) increase in HbA1c during pregnancy. When fasting glucose, 2h glucose and HbA1c during pregnancy were entered multivariable-adjusted model simultaneously, 2h glucose and HbA1c but not fasting glucose remained to be significant and positive predictors for postpartum diabetes. CONCLUSIONS: For women with prior GDM, 2h plasma glucose and HbA1c during pregnancy are independent predictors of postpartum diabetes, but fasting plasma glucose during pregnancy is not.
AIMS: Very few studies have assessed the association of fasting and 2h glucose, and HbA1c during pregnancy with postpartum diabetes risk among women with prior gestational diabetes mellitus (GDM). We assessed the association of fasting glucose, 2h glucose and HbA1c at 26-30 gestational weeks with postpartum diabetes risk among women with prior GDM. METHODS: A cohort study in 1263 GDM women at 1-5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of fasting and 2h plasma glucose, and HbA1c at 26-30 gestational weeks with the risk of diabetes at postpartum. RESULTS: The multivariable-adjusted (age, pre-pregnancy body mass index, weight gain during pregnancy, current body mass index, family history of diabetes, marital status, education, family income, smoking status, passive smoking, leisure-time physical activity, alcohol drinking, and intake of energy, saturated fat, and dietary fiber) hazard ratios of postpartum diabetes were 1.61 (95% confidence interval [CI]: 1.36-1.91) for each 1 mmol/l increase in fasting glucose during pregnancy, 1.63 (95% CI: 1.45-1.84) for each 1 mmol/l increase in 2h glucose during pregnancy, 2.11 (95% CI: 1.50-2.97) for each 1 unit (%) increase in HbA1c during pregnancy. When fasting glucose, 2h glucose and HbA1c during pregnancy were entered multivariable-adjusted model simultaneously, 2h glucose and HbA1c but not fasting glucose remained to be significant and positive predictors for postpartum diabetes. CONCLUSIONS: For women with prior GDM, 2h plasma glucose and HbA1c during pregnancy are independent predictors of postpartum diabetes, but fasting plasma glucose during pregnancy is not.
Authors: Aneta Malinowska-Polubiec; Jacek Sienko; Zbigniew Lewandowski; Krzysztof Czajkowski; Roman Smolarczyk Journal: Gynecol Endocrinol Date: 2012-03-05 Impact factor: 2.260
Authors: F Zhang; L Dong; C P Zhang; B Li; J Wen; W Gao; S Sun; F Lv; H Tian; J Tuomilehto; L Qi; C L Zhang; Z Yu; X Yang; G Hu Journal: Diabet Med Date: 2011-06 Impact factor: 4.359
Authors: Yujie Wang; Liwei Chen; Ke Xiao; Ronald Horswell; Jay Besse; Jolene Johnson; Donna H Ryan; Gang Hu Journal: J Womens Health (Larchmt) Date: 2011-10-24 Impact factor: 2.681
Authors: Soo Heon Kwak; Sung Hee Choi; Hye Seung Jung; Young Min Cho; Soo Lim; Nam H Cho; Seong Yeon Kim; Kyong Soo Park; Hak C Jang Journal: J Clin Endocrinol Metab Date: 2013-03-07 Impact factor: 5.958
Authors: Shuang Zhang; Huikun Liu; Cuiping Zhang; Leishen Wang; Nan Li; Junhong Leng; Yi Li; Gongshu Liu; Xiangwei Fan; Zhijie Yu; Xilin Yang; Andrea A Baccarelli; Lifang Hou; Gang Hu Journal: Biomed Res Int Date: 2015-02-23 Impact factor: 3.411
Authors: Yuxin Fan; Leishen Wang; Huikun Liu; Shuang Zhang; Huiguang Tian; Yun Shen; Jaakko Tuomilehto; Zhijie Yu; Xilin Yang; Gang Hu; Ming Liu Journal: BMJ Open Diabetes Res Care Date: 2020-09