Filip Spaniel1, Jaroslav Tintera2, Jan Rydlo2, Ibrahim Ibrahim2, Tomas Kasparek3, Jiri Horacek4, Yuliya Zaytseva5, Martin Matejka6, Marketa Fialova6, Andrea Slovakova6, Pavol Mikolas6, Tomas Melicher4, Natalie Görnerova4, Cyril Höschl4, Tomas Hajek7. 1. National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic; filip.spaniel@nudz.cz. 2. National Institute of Mental Health, Klecany, Czech Republic; MR-Unit ZRIR, IKEM, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 3. Department of Psychiatry, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 4. National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic; 5. National Institute of Mental Health, Klecany, Czech Republic; 6. National Institute of Mental Health, Klecany, Czech Republic; Psychiatric Hospital Bohnice, Prague, Czech Republic; 7. National Institute of Mental Health, Klecany, Czech Republic; Department of Psychiatry, Dalhousie University, Halifax, Canada.
Abstract
BACKGROUND: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. AIMS: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). METHOD: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). RESULTS: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. DISCUSSION: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
BACKGROUND: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. AIMS: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). METHOD: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). RESULTS: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. DISCUSSION: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
Authors: Jan Van Hecke; Thomas Edward Gladwin; Jean Coremans; Marianne Destoop; Wouter Hulstijn; Bernard Sabbe Journal: Brain Imaging Behav Date: 2013-03 Impact factor: 3.978
Authors: Andrei Manoliu; Valentin Riedl; Andriy Zherdin; Mark Mühlau; Dirk Schwerthöffer; Martin Scherr; Henning Peters; Claus Zimmer; Hans Förstl; Josef Bäuml; Afra M Wohlschläger; Christian Sorg Journal: Schizophr Bull Date: 2013-03-21 Impact factor: 9.306
Authors: Marián Kolenič; Filip Španiel; Jaroslav Hlinka; Martin Matějka; Pavel Knytl; Antonín Šebela; Jiří Renka; Tomas Hajek Journal: Front Psychiatry Date: 2020-09-23 Impact factor: 4.157