Agnese Gugliandolo1, Chiara Gangemi1, Carlo Calabrò1, Mercurio Vecchio1, Debora Di Mauro1, Marcella Renis2, Riccardo Ientile1, Monica Currò1, Daniela Caccamo3. 1. Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy. 2. Department of Drug Sciences, University of Catania, Viale Andrea Doria, 95100 Catania, Italy. 3. Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: dcaccamo@unime.it.
Abstract
AIMS: Oxidative stress increase is a key event for development of sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the influence of a genetic variant in the antioxidant enzyme glutathione peroxidase (GPx1) on oxidative stress development in SRIs. MAIN METHODS: GPx1 rs1800668 genotype, as well as glutathione, ubiquinone, and DNA damage were assessed in 34 SRI patients and 36 healthy subjects. KEY FINDINGS: Total glutathione, reduced/oxidized glutathione, and ubiquinone were significantly decreased in cases compared with controls, while DNA fragmentation was significantly increased in patients. However, these differences were not associated to GPx1 genetic background. SIGNIFICANCE: GPx1 rs1800668 polymorphism does not play a major role in SRI-related oxidative stress development.
AIMS: Oxidative stress increase is a key event for development of sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the influence of a genetic variant in the antioxidant enzyme glutathione peroxidase (GPx1) on oxidative stress development in SRIs. MAIN METHODS:GPx1rs1800668 genotype, as well as glutathione, ubiquinone, and DNA damage were assessed in 34 SRIpatients and 36 healthy subjects. KEY FINDINGS: Total glutathione, reduced/oxidized glutathione, and ubiquinone were significantly decreased in cases compared with controls, while DNA fragmentation was significantly increased in patients. However, these differences were not associated to GPx1 genetic background. SIGNIFICANCE: GPx1rs1800668 polymorphism does not play a major role in SRI-related oxidative stress development.
Authors: Christa Watson-Wright; Priscila Queiroz; Sylvia Rodrigues; Thomas C Donaghey; Joseph D Brain; Ramon M Molina Journal: Exp Lung Res Date: 2018-10-08 Impact factor: 2.459