Literature DB >> 26685753

Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide.

Koji Dogishi1, Mizuki Kodera1, Shohei Oyama1, Hisashi Shirakawa1, Takayuki Nakagawa2, Shuji Kaneko1.   

Abstract

We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition.
Copyright © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Chronic cystitis; Hydrogen peroxide; Painful bladder syndrome

Mesh：

Substances：

Year:  2015        PMID： 26685753     DOI： 10.1016/j.jphs.2015.11.003

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  6 in total

1.  Effect of Intravesical Liposome-Based Nerve Growth Factor Antisense Therapy on Bladder Overactivity and Nociception in a Rat Model of Cystitis Induced by Hydrogen Peroxide.

Authors:  Tsuyoshi Majima; Pradeep Tyagi; Koji Dogishi; Mahendra Kashyap; Yasuhito Funahashi; Momokazu Gotoh; Michael B Chancellor; Naoki Yoshimura
Journal:  Hum Gene Ther       Date:  2017-04-18       Impact factor: 5.695

Review 2.  Muro-Neuro-Urodynamics; a Review of the Functional Assessment of Mouse Lower Urinary Tract Function.

Authors:  Hiroki Ito; Anthony E Pickering; Yasuhiko Igawa; Anthony J Kanai; Christopher H Fry; Marcus J Drake
Journal:  Front Physiol       Date:  2017-02-06       Impact factor: 4.566

3.  A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide.

Authors:  Koji Dogishi; Ken Okamoto; Tsuyoshi Majima; Shizuka Konishi-Shiotsu; Takashi Homan; Mizuki Kodera; Shohei Oyama; Tatsuya Oyama; Hisashi Shirakawa; Naoki Yoshimura; Takayuki Nakagawa; Shuji Kaneko
Journal:  Physiol Rep       Date:  2017-02-27

4.  Direct conversion of fibroblasts into urothelial cells that may be recruited to regenerating mucosa of injured urinary bladder.

Authors:  Yuta Inoue; Tsunao Kishida; Shin-Ichiro Kotani; Mika Akiyoshi; Hideto Taga; Makoto Seki; Osamu Ukimura; Osam Mazda
Journal:  Sci Rep       Date:  2019-09-25       Impact factor: 4.379

5.  Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide.

Authors:  Shohei Oyama; Koji Dogishi; Mizuki Kodera; Masashi Kakae; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko
Journal:  Front Physiol       Date:  2017-11-07       Impact factor: 4.566

6.  Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1α in a rat cystitis model induced by hydrogen peroxide.

Authors:  S Takai; T Majima; B Reinhart; W F Goins; Y Funahashi; M Gotoh; P Tyagi; J C Glorioso; N Yoshimura
Journal:  Gene Ther       Date:  2017-10-20       Impact factor: 5.250
  6 in total

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