Literature DB >> 26685750

Cryptococcus: from environmental saprophyte to global pathogen.

Robin C May1, Neil R H Stone2, Darin L Wiesner3, Tihana Bicanic2, Kirsten Nielsen3.   

Abstract

Cryptococcosis is a globally distributed invasive fungal infection that is caused by species within the genus Cryptococcus which presents substantial therapeutic challenges. Although natural human-to-human transmission has never been observed, recent work has identified multiple virulence mechanisms that enable cryptococci to infect, disseminate within and ultimately kill their human host. In this Review, we describe these recent discoveries that illustrate the intricacy of host-pathogen interactions and reveal new details about the host immune responses that either help to protect against disease or increase host susceptibility. In addition, we discuss how this improved understanding of both the host and the pathogen informs potential new avenues for therapeutic development.

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Year:  2015        PMID： 26685750      PMCID： PMC5019959          DOI： 10.1038/nrmicro.2015.6

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  134 in total

Review 1.  Evolution of intracellular pathogens.

Authors:  Arturo Casadevall
Journal:  Annu Rev Microbiol       Date:  2008       Impact factor: 15.500

2.  Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial.

Authors:  Sayoki Mfinanga; Duncan Chanda; Sokoine L Kivuyo; Lorna Guinness; Christian Bottomley; Victoria Simms; Carol Chijoka; Ayubu Masasi; Godfather Kimaro; Bernard Ngowi; Amos Kahwa; Peter Mwaba; Thomas S Harrison; Saidi Egwaga; Shabbar Jaffar
Journal:  Lancet       Date:  2015-03-10       Impact factor: 79.321

3.  Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier.

Authors:  Yun C Chang; Monique F Stins; Michael J McCaffery; Georgina F Miller; Dan R Pare; Tapen Dam; Maneesh Paul-Satyaseela; Kwang Sik Kim; Kyung J Kwon-Chung; Maneesh Paul-Satyasee
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

Review 4.  Spread of Cryptococcus gattii into Pacific Northwest region of the United States.

Authors:  Kausik Datta; Karen H Bartlett; Rebecca Baer; Edmond Byrnes; Eleni Galanis; Joseph Heitman; Linda Hoang; Mira J Leslie; Laura MacDougall; Shelley S Magill; Muhammad G Morshed; Kieren A Marr
Journal:  Emerg Infect Dis       Date:  2009-08       Impact factor: 6.883

5.  Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation.

Authors:  Sarah E Hardison; Gina Herrera; Mattie L Young; Camaron R Hole; Karen L Wozniak; Floyd L Wormley
Journal:  J Immunol       Date:  2012-09-14       Impact factor: 5.422

6.  Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole.

Authors:  Brunella Posteraro; Maurizio Sanguinetti; Dominique Sanglard; Marilena La Sorda; Stefania Boccia; Lucio Romano; Giulia Morace; Giovanni Fadda
Journal:  Mol Microbiol       Date:  2003-01       Impact factor: 3.501

7.  Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii.

Authors:  Anastasia P Litvintseva; Thomas G Mitchell
Journal:  PLoS Pathog       Date:  2012-02-23       Impact factor: 6.823

8.  Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.

Authors:  Deborah J Springer; R Blake Billmyre; Elan E Filler; Kerstin Voelz; Rhiannon Pursall; Piotr A Mieczkowski; Robert A Larsen; Fred S Dietrich; Robin C May; Scott G Filler; Joseph Heitman
Journal:  PLoS Pathog       Date:  2014-08-21       Impact factor: 6.823

9.  Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier.

Authors:  Tong-Bao Liu; Jong-Chul Kim; Yina Wang; Dena L Toffaletti; Eliseo Eugenin; John R Perfect; Kee Jun Kim; Chaoyang Xue
Journal:  PLoS Pathog       Date:  2013-04-04       Impact factor: 6.823

10.  Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages.

Authors:  Mauricio Alvarez; Arturo Casadevall
Journal:  BMC Immunol       Date:  2007-08-16       Impact factor: 3.615
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  117 in total

1.  Contribution of Laccase Expression to Immune Response against Cryptococcus gattii Infection.

Authors:  Adithap Hansakon; Popchai Ngamskulrungroj; Pornpimon Angkasekwinai
Journal:  Infect Immun       Date:  2020-02-20       Impact factor: 3.441

2.  The Inhalable Mycobiome of Sawmill Workers: Exposure Characterization and Diversity.

Authors:  Anne Straumfors; Oda A H Foss; Janina Fuss; Steen K Mollerup; Håvard Kauserud; Sunil Mundra
Journal:  Appl Environ Microbiol       Date:  2019-10-16       Impact factor: 4.792

3.  Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.

Authors:  Darin L Wiesner; Kyle D Smith; Sakeen W Kashem; Paul R Bohjanen; Kirsten Nielsen
Journal:  J Immunol       Date:  2017-01-09       Impact factor: 5.422

4.  Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood-brain barrier.

Authors:  Jin Kim; Kyung-Tae Lee; Jong Seung Lee; Jisoo Shin; Baofang Cui; Kisuk Yang; Yi Sun Choi; Nakwon Choi; Soo Hyun Lee; Jae-Hyun Lee; Yong-Sun Bahn; Seung-Woo Cho
Journal:  Nat Biomed Eng       Date:  2021-06-14       Impact factor: 25.671

Review 5.  Role of microglia in fungal infections of the central nervous system.

Authors:  George W Koutsouras; Raddy L Ramos; Luis R Martinez
Journal:  Virulence       Date:  2016-11-18       Impact factor: 5.882

6.  False-Negative Serum Cryptococcal Lateral Flow Assay Result Due to the Prozone Phenomenon.

Authors:  Gar-Hing Lee; Ian Arthur; Michael Leung
Journal:  J Clin Microbiol       Date:  2018-03-26       Impact factor: 5.948

7.  Cryptococcus gattii VGII isolated from native forest and river in Northern Brazil.

Authors:  Amaury Dos Santos Bentes; Bodo Wanke; Márcia Dos Santos Lazéra; Ana Karla Lima Freire; Roberto Moreira da Silva Júnior; Diego Fernando Silva Rocha; Silviane Bezerra Pinheiro; Steven Edward Zelski; Ani Beatriz Jackisch Matsuura; Liliane Coelho da Rocha; Erica Simplício de Souza; João Vicente Braga de Souza
Journal:  Braz J Microbiol       Date:  2019-03-09       Impact factor: 2.476

8.  The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans.

Authors:  Juliana Rizzo; Ana C Colombo; Daniel Zamith-Miranda; Vanessa K A Silva; Jeremy C Allegood; Arturo Casadevall; Maurizio Del Poeta; Joshua D Nosanchuk; James W Kronstad; Marcio L Rodrigues
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2017-12-29       Impact factor: 4.739

Review 9.  Fungal Pathogens: Shape-Shifting Invaders.

Authors:  Kyunghun Min; Aaron M Neiman; James B Konopka
Journal:  Trends Microbiol       Date:  2020-05-27       Impact factor: 17.079

Review 10.  Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy.

Authors:  Peter R Williamson; Joseph N Jarvis; Anil A Panackal; Matthew C Fisher; Síle F Molloy; Angela Loyse; Thomas S Harrison
Journal:  Nat Rev Neurol       Date:  2016-11-25       Impact factor: 42.937
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