Literature DB >> 26684632

Genetic polymorphisms and the development of invasive bacterial infections in children.

Susanna Esposito1, Samantha Bosis2, Annalisa Orenti3, Silvia Spena2, Valentina Montinaro2, Sonia Bianchini2, Alberto Zampiero2, Nicola Principi2.   

Abstract

To evaluate the associations between single nucleotide polymorphisms (SNPs) of factors involved in the development of invasive bacterial disease (IBD) in children, 47 SNPs of 18 candidate genes were analysed in 49 children with IBD and 100 controls. The G/T genotype of TLR2 rs2149356 and the C genotype of LTA rs2229094 were associated with significantly reduced risk of developing IBD (P=0.04 and P=0.05, respectively), whereas the C/T genotype of RFP175 rs1585110 was associated with a significantly higher risk of developing IBD (P=0.02). These results support the evidence that some genetic variants of factors involved in innate immunity may influence IBD risk in children.
© The Author(s) 2015.

Entities:  

Keywords:  Neisseria meningitidis; Streptococcus pneumoniae; adaptive immunity; genetic polymorphisms; innate immunity; invasive bacterial disease; sepsis

Mesh：

Substances：

Year:  2015        PMID： 26684632      PMCID： PMC5806737          DOI： 10.1177/0394632015622961

Source DB:  PubMed          Journal:  Int J Immunopathol Pharmacol        ISSN： 0394-6320            Impact factor:   3.219


  19 in total

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Journal:  Oncology       Date:  2012-01-26       Impact factor: 2.935

3.  Impact of genetic polymorphisms on paediatric atopic dermatitis.

Authors:  Susanna Esposito; Maria Francesca Patria; Silvia Spena; Claudio Codecà; Claudia Tagliabue; Alberto Zampiero; Mara Lelii; Valentina Montinaro; Claudio Pelucchi; Nicola Principi
Journal:  Int J Immunopathol Pharmacol       Date:  2015-06-29       Impact factor: 3.219

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Authors:  Joseph A Carcillo; Alan I Fields
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Review 5.  Human genetic susceptibility to infectious disease.

Authors:  Stephen J Chapman; Adrian V S Hill
Journal:  Nat Rev Genet       Date:  2012-02-07       Impact factor: 53.242

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Journal:  Malar J       Date:  2012-06-12       Impact factor: 2.979

7.  Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.

Authors:  Petr Jabandziev; Michal Smerek; Jaroslav Michalek; Michal Fedora; Lucie Kosinova; Jaroslav A Hubacek; Jaroslav Michalek
Journal:  Crit Care       Date:  2014-01-02       Impact factor: 9.097

8.  Genetic polymorphisms and risk of recurrent wheezing in pediatric age.

Authors:  Susanna Esposito; Valentina Ierardi; Cristina Daleno; Alessia Scala; Leonardo Terranova; Claudia Tagliabue; Walter Peves Rios; Claudio Pelucchi; Nicola Principi
Journal:  BMC Pulm Med       Date:  2014-10-18       Impact factor: 3.317

9.  Genetic polymorphisms and sepsis in premature neonates.

Authors:  Susanna Esposito; Alberto Zampiero; Lorenza Pugni; Silvia Tabano; Claudio Pelucchi; Beatrice Ghirardi; Leonardo Terranova; Monica Miozzo; Fabio Mosca; Nicola Principi
Journal:  PLoS One       Date:  2014-07-07       Impact factor: 3.240

10.  Genetic Polymorphisms of Functional Candidate Genes and Recurrent Acute Otitis Media With or Without Tympanic Membrane Perforation.

Authors:  Susanna Esposito; Paola Marchisio; Annalisa Orenti; Silvia Spena; Sonia Bianchini; Erica Nazzari; Chiara Rosazza; Alberto Zampiero; Elia Biganzoli; Nicola Principi
Journal:  Medicine (Baltimore)       Date:  2015-10       Impact factor: 1.817
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