Murat Çiftel1, Berrin Demir2, Günay Kozan3, Osman Yılmaz4, Hasan Kahveci5, Ömer Kılıç6. 1. Department of Pediatric Cardiology, Erzurum Region Training and Research Hospital, Erzurum, 25080, Turkey. nefrotik@hotmail.com. 2. Department of Radiology, Erzurum Training and Research Hospital, Erzurum, Turkey. 3. Department of Ear, Nose, and Throat, Erzurum Training and Research Hospital, Erzurum, Turkey. 4. Department of Pediatric Cardiology, Erzurum Region Training and Research Hospital, Erzurum, 25080, Turkey. 5. Neonatal unit, Erzurum Training and Research Hospital, Erzurum, Turkey. 6. Department of Pediatric Infectious Diseases, Erzurum Training and Research Hospital, Erzurum, Turkey.
Abstract
BACKGROUND: Adenotonsillar hypertrophy can produce cardiopulmonary disease in children. However, it is unclear whether adenotonsillar hypertrophy causes atherosclerosis. This study evaluated carotid intimamedia thickness and carotid arterial stiffness in children with adenotonsillar hypertrophy. METHODS: The study included 40 children with adenotonsillar hypertrophy (age: 5-10 years) and 36 healthy children with similar age and body mass index. Systolic blood pressure, diastolic blood pressure, and pulse pressure were measured in all subjects. Carotid intima-media thickness, carotid arterial systolic diameter, and carotid arterial diastolic diameter were measured using a high-resolution ultrasound device. Based on these measurements, carotid arterial strain, carotid artery distensibility, beta stiffness index, and elasticity modulus were calculated. RESULTS: Carotid intima-media thickness was greater in children with adenotonsillar hypertrophy (0.36±0.05 mm vs. 0.34±0.04 mm, P=0.02) compared to healthy controls. Beta stiffness index (3.01±1.22 vs. 2.98±0.98, P=0.85), elasticity modulus (231.39±99.23 vs. 226.46±83.20, P=0.88), carotid arterial strain (0.17±0.06 vs. 0.17±0.04, P=0.95), and carotid artery distensibility (13.14±3.88 vs. 12.92±3.84, P=0.75) were similar between children with adenotonsillar hypertrophy and the healthy controls. CONCLUSIONS: The present study revealed increased carotid intima-media thickness in children with adenotonsillar hypertrophy. The risk of subclinical atherosclerosis may be higher in children with adenotonsillar hypertrophy.
BACKGROUND:Adenotonsillar hypertrophy can produce cardiopulmonary disease in children. However, it is unclear whether adenotonsillar hypertrophy causes atherosclerosis. This study evaluated carotid intimamedia thickness and carotid arterial stiffness in children with adenotonsillar hypertrophy. METHODS: The study included 40 children with adenotonsillar hypertrophy (age: 5-10 years) and 36 healthy children with similar age and body mass index. Systolic blood pressure, diastolic blood pressure, and pulse pressure were measured in all subjects. Carotid intima-media thickness, carotid arterial systolic diameter, and carotid arterial diastolic diameter were measured using a high-resolution ultrasound device. Based on these measurements, carotid arterial strain, carotid artery distensibility, beta stiffness index, and elasticity modulus were calculated. RESULTS: Carotid intima-media thickness was greater in children with adenotonsillar hypertrophy (0.36±0.05 mm vs. 0.34±0.04 mm, P=0.02) compared to healthy controls. Beta stiffness index (3.01±1.22 vs. 2.98±0.98, P=0.85), elasticity modulus (231.39±99.23 vs. 226.46±83.20, P=0.88), carotid arterial strain (0.17±0.06 vs. 0.17±0.04, P=0.95), and carotid artery distensibility (13.14±3.88 vs. 12.92±3.84, P=0.75) were similar between children with adenotonsillar hypertrophy and the healthy controls. CONCLUSIONS: The present study revealed increased carotid intima-media thickness in children with adenotonsillar hypertrophy. The risk of subclinical atherosclerosis may be higher in children with adenotonsillar hypertrophy.
Authors: Jinkwan Kim; Rakesh Bhattacharjee; Ehab Dayyat; Ayelet B Snow; Leila Kheirandish-Gozal; Julie L Goldman; Richard C Li; Laura D Serpero; Heather B Clair; David Gozal Journal: Pediatr Res Date: 2009-10 Impact factor: 3.756
Authors: David F Smith; Christine L Schuler; Md M Hossain; Guixia Huang; Keith McConnell; Elaine M Urbina; Raouf S Amin Journal: J Pediatr Date: 2021-08-25 Impact factor: 6.314