Zheyuan Wu1, Juntao Guo1, Ying Huang2, Enmao Cai2, Xia Zhang2, Qichao Pan1, Zheng'an Yuan3, Xin Shen4. 1. Department of Tuberculosis Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. 2. Shanghai Changning Center for Disease Control and Prevention, Shanghai, China. 3. Department of Tuberculosis Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. Electronic address: yuanzhengan@scdc.sh.cn. 4. Department of Tuberculosis Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. Electronic address: shenxin@scdc.sh.cn.
Abstract
AIMS: To determine the prevalence of diabetes mellitus among pulmonary tuberculosis patients and the difference of clinical characteristics and outcomes between pulmonary tuberculosis patients with and without diabetes mellitus in an aging population in Shanghai, China. METHODS: This is a retrospective population-based study. 201 newly diagnosed pulmonary tuberculosis patients in Changning District, Shanghai during 2007-2008 were included. Clinical characteristics and outcomes were collected. Determination of diabetes mellitus was based on the medical records before pulmonary tuberculosis was diagnosed. RESULTS: The prevalence of diabetes mellitus among pulmonary tuberculosis patients was 19.9% (40/201). Pulmonary tuberculosis patients with diabetes mellitus were more likely to be old (≥50, OR=5.23, 95% CI=2.07-13.25), to have pulmonary cavities (OR=3.02, 95% CI=1.31-6.98), to be sputum smear positive (OR=2.90, 95% CI=1.12-7.51), and to have extension of anti-tuberculosis treatment duration (OR=2.68, 95% CI 1.17-6.14). Besides, they had a higher 2nd month sputum smear positive proportion (OR=2.97, 95% CI 1.22-7.22) and a higher 5-year recurrence rate (OR=5.87, 95% CI 1.26-27.40). CONCLUSIONS: High prevalence, severe clinical characteristics and poor outcomes of pulmonary tuberculosis patients with diabetes mellitus highlight the necessity of early bi-directional screening and co-management of these two diseases in Shanghai, China.
AIMS: To determine the prevalence of diabetes mellitus among pulmonary tuberculosispatients and the difference of clinical characteristics and outcomes between pulmonary tuberculosispatients with and without diabetes mellitus in an aging population in Shanghai, China. METHODS: This is a retrospective population-based study. 201 newly diagnosed pulmonary tuberculosispatients in Changning District, Shanghai during 2007-2008 were included. Clinical characteristics and outcomes were collected. Determination of diabetes mellitus was based on the medical records before pulmonary tuberculosis was diagnosed. RESULTS: The prevalence of diabetes mellitus among pulmonary tuberculosispatients was 19.9% (40/201). Pulmonary tuberculosispatients with diabetes mellitus were more likely to be old (≥50, OR=5.23, 95% CI=2.07-13.25), to have pulmonary cavities (OR=3.02, 95% CI=1.31-6.98), to be sputum smear positive (OR=2.90, 95% CI=1.12-7.51), and to have extension of anti-tuberculosis treatment duration (OR=2.68, 95% CI 1.17-6.14). Besides, they had a higher 2nd month sputum smear positive proportion (OR=2.97, 95% CI 1.22-7.22) and a higher 5-year recurrence rate (OR=5.87, 95% CI 1.26-27.40). CONCLUSIONS: High prevalence, severe clinical characteristics and poor outcomes of pulmonary tuberculosispatients with diabetes mellitus highlight the necessity of early bi-directional screening and co-management of these two diseases in Shanghai, China.
Authors: Yan Wei; Yingyao Chen; Yingnan Zhao; Russell Rothman; Jian Ming; Lei Wang; Xiaona Liu; Lizheng Shi; Wanghong Xu Journal: BMJ Open Diabetes Res Care Date: 2020-06