Lynn Babcock1, Weihong Yuan2, James Leach2, Tiffany Nash2, Shari Wade3. 1. Division of Pediatric Emergency Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. 2. Division of Radiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. 3. Division of Physical Medicine and Rehabilitation, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Abstract
PURPOSE: To examine acute alterations in white matter (WM) diffusion based on diffusion tensor imaging (DTI) in youth with mild traumatic brain injury (mTBI) relative to orthopedic injury (OI) controls. METHODS: A prospective cohort study of 23 patients with mTBI and 20 OI controls ages 11-16 years were recruited from the emergency department (ED). DTI was performed within 96 hours. Voxel based analysis quantified group differences for DTI indices: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). The Post Concussion Symptom Scale assessed symptom burden. RESULTS: Youth with mTBI had significantly higher symptom burdens in the ED and at scanning than controls. The mTBI group had significantly higher levels of FA and AD in several WM regions including the middle temporal gyrus WM, superior temporal gyrus WM, anterior corona radiata, and superior longitudinal fasciculus. The mTBI group had significantly lower levels of MD and/or RD in a few WM regions including the middle frontal gyrus WM and anterior corona radiata. Diffusion alterations correlated poorly with acute symptom burden. CONCLUSIONS: Alterations of diffusivity were detected in spatially heterogeneous WM regions shortly after mTBI in youth. The pattern of alterations may reflect restrictive water diffusion in WM early post-injury.
PURPOSE: To examine acute alterations in white matter (WM) diffusion based on diffusion tensor imaging (DTI) in youth with mild traumatic brain injury (mTBI) relative to orthopedic injury (OI) controls. METHODS: A prospective cohort study of 23 patients with mTBI and 20 OI controls ages 11-16 years were recruited from the emergency department (ED). DTI was performed within 96 hours. Voxel based analysis quantified group differences for DTI indices: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). The Post Concussion Symptom Scale assessed symptom burden. RESULTS: Youth with mTBI had significantly higher symptom burdens in the ED and at scanning than controls. The mTBI group had significantly higher levels of FA and AD in several WM regions including the middle temporal gyrus WM, superior temporal gyrus WM, anterior corona radiata, and superior longitudinal fasciculus. The mTBI group had significantly lower levels of MD and/or RD in a few WM regions including the middle frontal gyrus WM and anterior corona radiata. Diffusion alterations correlated poorly with acute symptom burden. CONCLUSIONS: Alterations of diffusivity were detected in spatially heterogeneous WM regions shortly after mTBI in youth. The pattern of alterations may reflect restrictive water diffusion in WM early post-injury.
Authors: Barbara Tavazzi; Stefano Signoretti; Giuseppe Lazzarino; Angela M Amorini; Roberto Delfini; Marco Cimatti; Anthony Marmarou; Roberto Vagnozzi Journal: Neurosurgery Date: 2005-03 Impact factor: 4.654
Authors: Laura Miles; Robert I Grossman; Glyn Johnson; James S Babb; Leonard Diller; Matilde Inglese Journal: Brain Inj Date: 2008-02 Impact factor: 2.311
Authors: Mark Jenkinson; Christian F Beckmann; Timothy E J Behrens; Mark W Woolrich; Stephen M Smith Journal: Neuroimage Date: 2011-09-16 Impact factor: 6.556
Authors: Cyrus A Raji; Maxwell B Wang; NhuNhu Nguyen; Julia P Owen; Eva M Palacios; Esther L Yuh; Pratik Mukherjee Journal: Pediatr Radiol Date: 2020-06-30
Authors: Marsh Königs; L W Ernest van Heurn; Roel Bakx; R Jeroen Vermeulen; J Carel Goslings; Bwee Tien Poll-The; Marleen van der Wees; Coriene E Catsman-Berrevoets; Jaap Oosterlaan; Petra J W Pouwels Journal: Hum Brain Mapp Date: 2017-04-21 Impact factor: 5.038
Authors: Andrew R Mayer; Mayank Kaushal; Andrew B Dodd; Faith M Hanlon; Nicholas A Shaff; Rebekah Mannix; Christina L Master; John J Leddy; David Stephenson; Christopher J Wertz; Elizabeth M Suelzer; Kristy B Arbogast; Timothy B Meier Journal: Neurosci Biobehav Rev Date: 2018-08-09 Impact factor: 8.989
Authors: Emily L Dennis; Talin Babikian; Christopher C Giza; Paul M Thompson; Robert F Asarnow Journal: Childs Nerv Syst Date: 2017-09-06 Impact factor: 1.475
Authors: Jesse S Shapiro; Michael Takagi; Tim Silk; Nicholas Anderson; Cathriona Clarke; Gavin A Davis; Stephen J C Hearps; Vera Ignjatovic; Vanessa Rausa; Marc L Seal; Franz E Babl; Vicki Anderson Journal: J Neurotrauma Date: 2021-07-30 Impact factor: 4.869
Authors: Gregory D Myer; Weihong Yuan; Kim D Barber Foss; Staci Thomas; David Smith; James Leach; Adam W Kiefer; Chris Dicesare; Janet Adams; Paul J Gubanich; Katie Kitchen; Daniel K Schneider; Daniel Braswell; Darcy Krueger; Mekibib Altaye Journal: Br J Sports Med Date: 2016-06-15 Impact factor: 13.800
Authors: Alina K Fong; Mark D Allen; Dana Waltzman; Kelly Sarmiento; Keith Owen Yeates; Stacy Suskauer; Max Wintermark; Daniel M Lindberg; David F Tate; Elizabeth A Wilde; Jaycie L Loewen Journal: J Neurotrauma Date: 2020-10-21 Impact factor: 5.269
Authors: João Paulo Lima Santos; Anthony P Kontos; Sarrah Mailliard; Shawn R Eagle; Cynthia L Holland; Stephen J Suss; Halimah Abdul-Waalee; Richelle S Stiffler; Hannah B Bitzer; Nicholas A Blaney; Adam T Colorito; Christopher G Santucci; Allison Brown; Tae Kim; Satish Iyengar; Alexander Skeba; Rasim S Diler; Cecile D Ladouceur; Mary L Phillips; David Brent; Michael W Collins; Amelia Versace Journal: Front Neurol Date: 2021-06-24 Impact factor: 4.003