| Literature DB >> 26683670 |
Noriyuki Yanagida, Takanori Imai, Sakura Sato, Motohiro Ebisawa.
Abstract
Entities:
Year: 2015 PMID: 26683670 PMCID: PMC4684278 DOI: 10.1371/journal.pone.0145567
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Grading of symptoms.
| 1 (mild) | 2 (moderate) | 3 (severe) | |
|---|---|---|---|
| Skin | Localized urticarial or exanthema or wheal or pruritis | Generalized urticarial or exanthema or wheal or pruritis | - |
| Swollen eyelid or lip | Swollen face | - | |
| Gastrointestinal tract | Pruritus of the throat or oral cavity | Throat pain | - |
| Mild abdominal pain | Moderate abdominal pain | Cramps | |
| Nausea, emesis, diarrhea | Recurrent emesis or diarrhea | Continuous emesis, loss of bowel control | |
| Respiratory tract | Intermittent cough, nasal congestion, sneezing, rhinorrhea | Repetitive cough | Persistent cough, hoarseness, “barky” cough |
| - | Chest tightness, mild wheezing | Apparent wheezing, dyspnea, cyanosis, saturation <92%, swallowing or speaking difficulties, throat tightness, respiratory arrest | |
| Cardiovascular | - | Pale face, mild hypotension, tachycardia (increase >15 beats/min) | Hypotension, dysrhythmia, severe bradycardia, cardiac arrest |
| Neurological | Change in activity level, tiredness | “Light-headedness,” feeling of “pending doom,” somnolence | Confusion, loss of consciousness, incontinence |
The severity score should be based on the organ system most affected.
Hypotension was defined as systolic blood pressure of <70 mmHg (ages, 1 month to 1 year), <(70 mmHg + [2 × age]) (ages, 1–10 years), and <90 mmHg (>11 years).
Mild hypotension was defined as systolic blood pressure of <80 mmHg (ages, 1 month to 1 year), <(80 mmHg + [2 × age]) (ages, 1–10 years), and <100 mmHg (>11 years).
Total severity scores were defined as the grade of cardiovascular symptoms + the grade of respiratory symptoms + the maximum grade of other symptoms.