Dong-Wha Kang1, Moon-Ku Han2, Hye-Jin Kim2, Hoyon Sohn2, Bum Joon Kim2, Sun U Kwon2, Jong S Kim2, Steven Warach2. 1. From the Department of Neurology (D.-W.K., H.-J.K., H.S., B.J.K., S.U.K., J.S.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; Department of Neurology (M.-K.H.), Seoul National University Bundang Hospital, Seongnam, South Korea; and Department of Neurology (S.W.), Dell Medical School University of Texas at Austin. dwkang@amc.seoul.kr. 2. From the Department of Neurology (D.-W.K., H.-J.K., H.S., B.J.K., S.U.K., J.S.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; Department of Neurology (M.-K.H.), Seoul National University Bundang Hospital, Seongnam, South Korea; and Department of Neurology (S.W.), Dell Medical School University of Texas at Austin.
Abstract
OBJECTIVE: To test whether a silent new ischemic lesion (SNIL) on MRI after stroke predicted future recurrent ischemic stroke or vascular events. METHODS: In this prospective study, we analyzed data from patients presenting with acute ischemic stroke who underwent MRI <24 hours and 5 and 30 days after symptom onset. The presence of a SNIL at 5 (5D-SNIL) and 30 (30D-SNIL) days was determined on diffusion-weighted and fluid-attenuated inversion recovery images. Patients were contacted every 3-6 months to identify recurrent clinical events. The log-rank test and Cox proportional hazard model were used to estimate the hazard ratio of recurrent ischemic stroke and composites of recurrent ischemic stroke, transient ischemic attack, acute coronary syndrome, and vascular death. RESULTS: The 5D- and 30D-SNILs were found in 24.4% (66/270) and 7.4% (19/256) of patients. During the 5-year follow-up, clinical events were observed in 42 patients (15.6%). The 5D- and 30D-SNIL independently predicted recurrent ischemic stroke (hazard ratio [95% confidence interval] 2.9 [1.3-6.4] and 9.6 [4.1-22.1], respectively) and composite vascular events (2.4 [1.3-4.5] and 6.1 [3.1-12.4], respectively). CONCLUSIONS: Patients with a SNIL within the first few weeks after index stroke have an increased risk of recurrent ischemic stroke or vascular events. The presence of a SNIL on MRI could serve as a surrogate endpoint for clinical recurrence in secondary prevention clinical trials.
OBJECTIVE: To test whether a silent new ischemic lesion (SNIL) on MRI after stroke predicted future recurrent ischemic stroke or vascular events. METHODS: In this prospective study, we analyzed data from patients presenting with acute ischemic stroke who underwent MRI <24 hours and 5 and 30 days after symptom onset. The presence of a SNIL at 5 (5D-SNIL) and 30 (30D-SNIL) days was determined on diffusion-weighted and fluid-attenuated inversion recovery images. Patients were contacted every 3-6 months to identify recurrent clinical events. The log-rank test and Cox proportional hazard model were used to estimate the hazard ratio of recurrent ischemic stroke and composites of recurrent ischemic stroke, transient ischemic attack, acute coronary syndrome, and vascular death. RESULTS: The 5D- and 30D-SNILs were found in 24.4% (66/270) and 7.4% (19/256) of patients. During the 5-year follow-up, clinical events were observed in 42 patients (15.6%). The 5D- and 30D-SNIL independently predicted recurrent ischemic stroke (hazard ratio [95% confidence interval] 2.9 [1.3-6.4] and 9.6 [4.1-22.1], respectively) and composite vascular events (2.4 [1.3-4.5] and 6.1 [3.1-12.4], respectively). CONCLUSIONS:Patients with a SNIL within the first few weeks after index stroke have an increased risk of recurrent ischemic stroke or vascular events. The presence of a SNIL on MRI could serve as a surrogate endpoint for clinical recurrence in secondary prevention clinical trials.
Authors: R L Sacco; E J Benjamin; J P Broderick; M Dyken; J D Easton; W M Feinberg; L B Goldstein; P B Gorelick; G Howard; S J Kittner; T A Manolio; J P Whisnant; P A Wolf Journal: Stroke Date: 1997-07 Impact factor: 7.914
Authors: Ernst-Wilhelm Radue; Paul O'Connor; Chris H Polman; Reinhard Hohlfeld; Peter Calabresi; Krystof Selmaj; Nicole Mueller-Lenke; Catherine Agoropoulou; Frederick Holdbrook; Ana de Vera; Lixin Zhang-Auberson; Gordon Francis; Pascale Burtin; Ludwig Kappos Journal: Arch Neurol Date: 2012-10