Lin Tian1, Chun Meng2, Ying Jiang3, Qunfeng Tang4, Shuai Wang5, Xiyao Xie6, Xiangshuai Fu5, Chunhui Jin5, Fuquan Zhang5, Jidong Wang7. 1. Department of Psychiatry, Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China; Wuxi Tongren International Rehabilitation Hospital, Wuxi, China. Electronic address: tianz@njmu.edu.cn. 2. Departments of Neuroradiology, TUM-Neuroimaging Center of Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. 3. Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, China. 4. Department of Medical Imaging, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China. 5. Department of Psychiatry, Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China; Wuxi Tongren International Rehabilitation Hospital, Wuxi, China. 6. Department of Psychology, Ludwig-Maximilians-Universität München, Munich, Germany. 7. Department of Psychiatry, Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China; Wuxi Tongren International Rehabilitation Hospital, Wuxi, China. Electronic address: wangjd9178@126.com.
Abstract
OBJECTIVE: Abnormal brain networks have been observed in patients with obsessive-compulsive disorder (OCD). However, detailed network hub and connectivity changes remained unclear in treatment-naive patients with OCD. Here, we sought to determine whether patients show hub-related connectivity changes in their whole-brain functional networks. METHODS: We used resting-state functional magnetic resonance imaging data and voxel-based graph-theoretic analysis to investigate functional connectivity strength and hubs of whole-brain networks in 29 treatment-naive patients with OCD and 29 age- and gender-matched healthy controls. Correlation analysis was applied for potential associations with OCD symptom severity. RESULTS: OCD selectively targeted brain regions of higher functional connectivity strength than the average including brain network hubs, mainly distributed in the cortico-striato-thalamo-cortical (CSTC) circuits and additionally parietal, occipital, temporal and cerebellar regions. Moreover, affected functional connectivity strength in the cerebellum, the medial orbitofrontal cortex and superior occipital cortex was significantly associated with global OCD symptom severity. CONCLUSION: Our results provide the evidence about OCD-related brain network hub changes, not only in the CSTC circuits but more distributed in whole brain networks. Data suggest that whole brain network hub analysis is useful for understanding the pathophysiology of OCD.
OBJECTIVE: Abnormal brain networks have been observed in patients with obsessive-compulsive disorder (OCD). However, detailed network hub and connectivity changes remained unclear in treatment-naive patients with OCD. Here, we sought to determine whether patients show hub-related connectivity changes in their whole-brain functional networks. METHODS: We used resting-state functional magnetic resonance imaging data and voxel-based graph-theoretic analysis to investigate functional connectivity strength and hubs of whole-brain networks in 29 treatment-naive patients with OCD and 29 age- and gender-matched healthy controls. Correlation analysis was applied for potential associations with OCD symptom severity. RESULTS:OCD selectively targeted brain regions of higher functional connectivity strength than the average including brain network hubs, mainly distributed in the cortico-striato-thalamo-cortical (CSTC) circuits and additionally parietal, occipital, temporal and cerebellar regions. Moreover, affected functional connectivity strength in the cerebellum, the medial orbitofrontal cortex and superior occipital cortex was significantly associated with global OCD symptom severity. CONCLUSION: Our results provide the evidence about OCD-related brain network hub changes, not only in the CSTC circuits but more distributed in whole brain networks. Data suggest that whole brain network hub analysis is useful for understanding the pathophysiology of OCD.
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