Literature DB >> 26682839

Dapsone hypersensitivity syndrome not related to G6PD deficiency.

Karlijn J G Schulkes1, J W Cohen Tervaert2, Feiko Rijken3, Lenneke E M Haas4.   

Abstract

Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID： 26682839      PMCID： PMC4691858          DOI： 10.1136/bcr-2015-212742

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  5 in total

1.  Development of dapsone toxicity in patients with inflammatory dermatoses: activity of acetylation and hydroxylation of dapsone as risk factors.

Authors:  R E Bluhm; A Adedoyin; D G McCarver; R A Branch
Journal:  Clin Pharmacol Ther       Date:  1999-06       Impact factor: 6.875

2.  T-cell plasticity of dapsone and DRESS.

Authors:  Alina Markova; Rene Duquesnoy; William Levis
Journal:  J Drugs Dermatol       Date:  2014-01       Impact factor: 2.114

3.  Dapsone for the treatment of chronic IgA vasculitis (Henoch-Schonlein).

Authors:  A P Bech; L J Reichert; J W Cohen Tervaert
Journal:  Neth J Med       Date:  2013-05       Impact factor: 1.422

4.  HLA-B*13:01 and the dapsone hypersensitivity syndrome.

Authors:  F-R Zhang; H Liu; A Irwanto; X-A Fu; Y Li; G-Q Yu; Y-X Yu; M-F Chen; H-Q Low; J-H Li; F-F Bao; J-N Foo; J-X Bei; X-M Jia; J Liu; H Liany; N Wang; G-Y Niu; Z-Z Wang; B-Q Shi; H-Q Tian; H-X Liu; S-S Ma; Y Zhou; J-B You; Q Yang; C Wang; T-S Chu; D-C Liu; X-L Yu; Y-H Sun; Y Ning; Z-H Wei; S-L Chen; X-C Chen; Z-X Zhang; Y-X Liu; S L Pulit; W-B Wu; Z-Y Zheng; R-D Yang; H Long; Z-S Liu; J-Q Wang; M Li; L-H Zhang; H Wang; L-M Wang; P Xiao; J-L Li; Z-M Huang; J-X Huang; Z Li; J Liu; L Xiong; J Yang; X-D Wang; D-B Yu; X-M Lu; G-Z Zhou; L-B Yan; J-P Shen; G-C Zhang; Y-X Zeng; P I W de Bakker; S-M Chen; J-J Liu
Journal:  N Engl J Med       Date:  2013-10-24       Impact factor: 91.245

5.  Mortality due to dapsone hypersensitivity syndrome complicating multi-drug therapy for leprosy in Nepal.

Authors:  B Pandey; K Shrestha; J Lewis; R A Hawksworth; S L Walker
Journal:  Trop Doct       Date:  2007-07       Impact factor: 0.731
  5 in total

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