Modified MgFe2O4 Ferrimagnetic Nanoparticles to Improve Magnetic and AC Magnetically-Induced Heating Characteristics for Hyperthermia.

A ferrimagnetic nanoparticle with a smaller size, a narrower size distribution, and a higher ac heat generation ability has been still studied for intra-arterial or intra-tumoral hyperthermia. In this study, we manipulate the calcining temperature in the range of 400-600 degrees C to modify MgFe2O4 ferrimagnetic nanoparticles (FMNPs) during modified sol-gel process. The modified MgFe2O4 FMNPs have well controlled with small size and narrow size distribution, so that their magnetic and ac magnetically-induced heating characteristics are significantly improved. In particular, MgFe2O4 nanoparticles synthesized at the calcining temperature of 600 degrees C and sintering temperature of 700 degrees C show the most suitable size (58 nm ± 13 nm) and its distribution (22%) resulting in the highest ac magnetically-induced heating temperature (T(AC,mag), ΔT = 93 degrees C) and SLP (Specific Loss Power, 600 W/g) at the biologically tolerable range of magnetic field (H(appl) = 140 Oe) and frequency (f(appl) = 110 kHz). It is found to be due to the improvement of magnetic softness and saturation magnetization resulting in the largest hysteresis loss power. All the results in this work clearly demonstrate that calcining process is one of the key parameters to control the proper size and size distribution for improving magnetic and ac magnetically-induced heating characteristics of MgFe2O4 FMNPs, which can be applicable to hyperthermia agents in nanomedicine.