BACKGROUND/AIMS: New-onset diabetes after transplantation (NODAT) is a serious complication of liver transplantation (LT). The present study aimed to investigate the risk factors of NODAT by a national survey using the China Liver Transplant Registry database. PATIENTS: A total of 10 204 non-pre-existing diabetic patients undergone primary LT between January 2000 and December 2013 were included. Risk factors were identified by logistic regression analysis. RESULTS: NODAT occurred in 24.3% of liver recipients with a median follow-up time of 2.6 years, and was associated with a significantly lower patient survival. NODAT increased not only diabetes related complications (e.g., infection, kidney failure) but also biliary stricture and cholangitis. NODAT patients who received hypoglycaemic treatment had a worse prognosis and a higher hepatocellular carcinoma recurrence compared with those without treatment. New-onset hyperglycaemia (<30 days) was the major predictor of NODAT. Other risk factors included cold ischaemia time >9 h, recipient age >50 years, body mass index >25 kg/m(2) , other hepatitis (mainly hepatitis C), post-transplant intensive care unit stay >15 days, cytomegalovirus infection and corticosteroid at discharge. CONCLUSIONS: The incidence of NODAT in China is similar to that in Western countries. However, the NODAT-related complications are more common and severer in China compared with those in Western countries. The major risk factors are different.
BACKGROUND/AIMS: New-onset diabetes after transplantation (NODAT) is a serious complication of liver transplantation (LT). The present study aimed to investigate the risk factors of NODAT by a national survey using the China Liver Transplant Registry database. PATIENTS: A total of 10 204 non-pre-existing diabeticpatients undergone primary LT between January 2000 and December 2013 were included. Risk factors were identified by logistic regression analysis. RESULTS: NODAT occurred in 24.3% of liver recipients with a median follow-up time of 2.6 years, and was associated with a significantly lower patient survival. NODAT increased not only diabetes related complications (e.g., infection, kidney failure) but also biliary stricture and cholangitis. NODAT patients who received hypoglycaemic treatment had a worse prognosis and a higher hepatocellular carcinoma recurrence compared with those without treatment. New-onset hyperglycaemia (<30 days) was the major predictor of NODAT. Other risk factors included cold ischaemia time >9 h, recipient age >50 years, body mass index >25 kg/m(2) , other hepatitis (mainly hepatitis C), post-transplant intensive care unit stay >15 days, cytomegalovirus infection and corticosteroid at discharge. CONCLUSIONS: The incidence of NODAT in China is similar to that in Western countries. However, the NODAT-related complications are more common and severer in China compared with those in Western countries. The major risk factors are different.
Authors: Jong Man Kim; Shin Hwang; Kwang-Woong Lee; Jae-Geun Lee; Je Ho Ryu; Bong-Wan Kim; Dong Lak Choi; Young Kyoung You; Dong-Sik Kim; Yang Won Nah; Koo Jeong Kang; Jai Young Cho; Geun Hong; In Seok Choi; Hee Chul Yu; Dongho Choi; Myoung Soo Kim Journal: Hepatobiliary Surg Nutr Date: 2020-08 Impact factor: 7.293
Authors: Elisabeth Schwaiger; Simon Krenn; Amelie Kurnikowski; Leon Bergfeld; María José Pérez-Sáez; Alexander Frey; David Topitz; Michael Bergmann; Sebastian Hödlmoser; Friederike Bachmann; Fabian Halleck; Susanne Kron; Hildegard Hafner-Giessauf; Kathrin Eller; Alexander R Rosenkranz; Marta Crespo; Anna Faura; Andrea Tura; Peter X K Song; Friedrich K Port; Julio Pascual; Klemens Budde; Robin Ristl; Johannes Werzowa; Manfred Hecking Journal: J Am Soc Nephrol Date: 2021-08 Impact factor: 14.978