| Literature DB >> 26681510 |
Hitomi Nishino1, Yuki Nakajima1, Yoshiaki Kakubari1, Nakata Asami1, Jun Deguchi1, Alfarius Eko Nugroho1, Yusuke Hirasawa1, Toshio Kaneda1, Yoko Kawasaki2, Yukihiro Goda2, Hiroshi Morita3.
Abstract
Oxomollugin (2) is a degradation product of mollugin (1) and a potent inhibitor of NO-production including nuclear factor kappa B signals. In our endeavor to develop a potent anti-inflammatory compound, we synthesized several aza-derivatives of oxomollugin (2) and evaluated their NO-production inhibitory activity. Azamollugin (3) showed a potent inhibitory activity, and its activity (IC50 0.34μM) was proved to be more potent than that of oxomollugin (2, IC50 1.3μM).Entities:
Keywords: Anti-inflammation; Azamollugin; Mollugin; NO-production inhibitor; Oxomollugin
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Year: 2015 PMID： 26681510 DOI： 10.1016/j.bmcl.2015.11.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823