| Literature DB >> 26681457 |
Yasutaka Okabe1, Ruslan Medzhitov1.
Abstract
Macrophages are essential components of mammalian tissues. Although historically known mainly for their function in host defense and the clearance of apoptotic cells, macrophages are now increasingly recognized as serving many roles in tissue development, homeostasis and repair. In addition, tissue-resident macrophages have many tissue-specific functional characteristics, which are a reflection of distinct gene-expression programs. Here we discuss the emerging views of macrophage biology from evolutionary, developmental and homeostatic perspectives.Entities:
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Year: 2016 PMID: 26681457 DOI: 10.1038/ni.3320
Source DB: PubMed Journal: Nat Immunol ISSN: 1529-2908 Impact factor: 25.606