S Y Lee1, S H Chu2, E G Oh3, K H Huh4. 1. Department of Adult Clinical Nursing, The Graduate School of Nursing, Yonsei University, Seoul, Korea; Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Korea. 2. Department of Clinical Nursing Science, Nursing Policy Research Institute, Yonsei University College of Nursing, Seoul, Korea. Electronic address: shchu@yuhs.ac. 3. Department of Clinical Nursing Science, Nursing Policy Research Institute, Yonsei University College of Nursing, Seoul, Korea. 4. Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Korea.
Abstract
PURPOSE: The purpose of this study was to investigate the relationship between immunosuppressant-related symptom experience (SE) and adherence to immunosuppressant regimens among kidney transplant (KT) recipients. METHODS: A total of 239 KT recipients on an immunosuppressant regimen who were followed up after transplantation participated in this study. Data was collected through a self-reported questionnaire survey (medication adherence, SE, and quality of life) and medical record review. RESULTS: Low adherence in the immunosuppressant group was associated with longer time since KT, less comorbidity (<3), and a higher rehospitalization rate. Low adherence among KT recipients showed significantly greater overall symptom occurrence (P = .001) and symptom distress (P = .002) levels than patients with high or medium adherence after adjusting for a number of covariates. The most common symptom both in terms of occurrence (96.4%) and distress (91.1%) among poorly adherent KT recipients was tiredness. CONCLUSION: Low adherence to an immunosuppressant regimen was significantly associated with high SE among KT recipients. Strategies to decrease immunosuppressant-related SE are needed to improve adherence to immunosuppressants.
PURPOSE: The purpose of this study was to investigate the relationship between immunosuppressant-related symptom experience (SE) and adherence to immunosuppressant regimens among kidney transplant (KT) recipients. METHODS: A total of 239 KT recipients on an immunosuppressant regimen who were followed up after transplantation participated in this study. Data was collected through a self-reported questionnaire survey (medication adherence, SE, and quality of life) and medical record review. RESULTS: Low adherence in the immunosuppressant group was associated with longer time since KT, less comorbidity (<3), and a higher rehospitalization rate. Low adherence among KT recipients showed significantly greater overall symptom occurrence (P = .001) and symptom distress (P = .002) levels than patients with high or medium adherence after adjusting for a number of covariates. The most common symptom both in terms of occurrence (96.4%) and distress (91.1%) among poorly adherent KT recipients was tiredness. CONCLUSION: Low adherence to an immunosuppressant regimen was significantly associated with high SE among KT recipients. Strategies to decrease immunosuppressant-related SE are needed to improve adherence to immunosuppressants.
Authors: Mary Amanda Dew; Donna M Posluszny; Andrea F DiMartini; Larissa Myaskovsky; Jennifer L Steel; Annette J DeVito Dabbs Journal: Curr Transplant Rep Date: 2018-04-17
Authors: Emily L Tucker; Abigail R Smith; Mark S Daskin; Hannah Schapiro; Sabrina M Cottrell; Evelyn S Gendron; Peg Hill-Callahan; Alan B Leichtman; Robert M Merion; Stephen J Gill; Kayse Lee Maass Journal: BMC Nephrol Date: 2019-05-16 Impact factor: 2.388