Literature DB >> 26679131

The tribulations of toothpaste trials: Unethical arginine dentifrice research.

D Shaw1, A Naimi-Akbar2, A Astvaldsdottir2.   

Abstract

Arginine toothpaste is being promoted as being more efficacious than conventional fluoride-only toothpaste. Recent revelations concerning the design and conduct of the clinical trials conducted on schoolchildren in China and Thailand cast serious doubt on these claims. This paper describes and analyses the ethical and design flaws affecting these studies.

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Year:  2015        PMID： 26679131     DOI： 10.1038/sj.bdj.2015.950

Source DB:  PubMed          Journal:  Br Dent J        ISSN： 0007-0610            Impact factor:   1.626


  5 in total

Review 1.  The relevance of relevance in research.

Authors:  Davud Shaw; Bernice S Elger
Journal:  Swiss Med Wkly       Date:  2013-05-07       Impact factor: 2.193

2.  Two-year caries clinical study of the efficacy of novel dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride.

Authors:  P Kraivaphan; C Amornchat; T Triratana; L R Mateo; R Ellwood; D Cummins; W DeVizio; Y-P Zhang
Journal:  Caries Res       Date:  2013-08-28       Impact factor: 4.056

3.  Comparison of the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of early coronal caries as assessed using Quantitative Light-induced Fluorescence.

Authors:  P Srisilapanan; N Korwanich; W Yin; C Chuensuwonkul; L R Mateo; Y P Zhang; D Cummins; R P Ellwood
Journal:  J Dent       Date:  2013-08       Impact factor: 4.379

4.  A clinical investigation using quantitative light-induced fluorescence (QLF) of the anticaries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate.

Authors:  W Yin; D Y Hu; X Fan; Y Feng; Y P Zhang; D Cummins; L R Mateo; I A Pretty; R P Ellwood
Journal:  J Clin Dent       Date:  2013

5.  The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF).

Authors:  W Yin; D Y Hu; X Li; X Fan; Y P Zhang; I A Pretty; L R Mateo; D Cummins; R P Ellwood
Journal:  J Dent       Date:  2013-08       Impact factor: 4.379
  5 in total
  3 in total

1.  Right of reply: A proud contribution.

Authors:  W DeVizio; R Ellwood
Journal:  Br Dent J       Date:  2016-01-15       Impact factor: 1.626

Review 2.  Beyond Streptococcus mutans: clinical implications of the evolving dental caries aetiological paradigms and its associated microbiome.

Authors:  N Philip; B Suneja; L Walsh
Journal:  Br Dent J       Date:  2018-02-16       Impact factor: 1.626

3.  Comment on the paper entitled 'Arginine and caries prevention: A systematic review'.

Authors: 
Journal:  Br Dent J       Date:  2017-06-23       Impact factor: 1.626
  3 in total

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