| Literature DB >> 26678891 |
Guodong Li1,2, Lei Yao3, Jinning Zhang1,2, Xinglong Li1,2, Shuwei Dang1,2, Kai Zeng1,2, Yuhui Zhou1,2, Feng Gao4.
Abstract
The tumor protein D52 (TPD52) is an oncogene overexpressed in breast cancer. Although the oncogenic effects of TPD52 are well recognized, how its expression and the role in migration/invasion is still not clear. This study tried to explore the regulative role of microRNA-34a (miR-34a), a tumor suppressive miRNA, on TPD52 expression in breast cancer. The expression of miR-34a was found significantly decreased in breast cancer specimens with lymph node metastases and breast cancer cell lines. The clinicopathological characteristics analyzed showed that lower expression levels of miR-34a were associated with advanced clinical stages. Moreover, TPD52 was demonstrated as one of miR-34a direct targets in human breast cancer cells. miR-34a was further found significantly repress epithelial-mesenchymal transition (EMT) and inhibit breast cancer cell migration and invasion via TPD52. These findings indicate that miR-34a inhibits breast cancer progression and metastasis through targeting TPD52. Consequently, our data strongly suggested that oncogenic TPD52 pathway regulated by miR-34a might be useful to reveal new therapeutic targets for breast cancer.Entities:
Keywords: Epithelial-mesenchymal transition; Human breast cancer; TPD52; miR-34a
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Year: 2015 PMID： 26678891 DOI： 10.1007/s13277-015-4623-4
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283