Xirong Xiao1, Yan Zhao2, Rong Jin3, Jiao Chen2, Xiu Wang2, Andrea Baccarelli4, Yunhui Zhang2. 1. Obstetrics & Gynecology Hospital, Fudan University, Shanghai 200032, China. 2. Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. 3. The International Peace Maternity & Child Health Hospital of China Welfare Institute, Shanghai 200032, China. 4. Departments of Environmental Health, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Abstract
AIM: To examine the associations between fetal growth restriction (FGR) and DNA methylation of six growth-related genes in human placenta. MATERIALS & METHODS: A total of 181 mother-newborn pairs (80 FGR cases and 101 controls) were enrolled in this case-control study. Placental DNA methylation was measured by bisulfite pyrosequencing. RESULTS: DNA methylation levels of IGF2 and AHRR were positively associated with newborn birth weight and Quetelet's index, while DNA methylation levels of HSD11B2 and WNT2 were negatively associated with those fetal growth indicators. In addition, significantly elevated odds of FGR birth were associated with increasing DNA methylation of HSD11B2 and WNT2, and decreasing DNA methylation of IGF2. CONCLUSION: Our findings demonstrated that placental DNA methylation levels of IGF2, AHRR, HSD11B2 and WNT2 were associated with measures of fetal growth.
AIM: To examine the associations between fetal growth restriction (FGR) and DNA methylation of six growth-related genes in human placenta. MATERIALS & METHODS: A total of 181 mother-newborn pairs (80 FGR cases and 101 controls) were enrolled in this case-control study. Placental DNA methylation was measured by bisulfite pyrosequencing. RESULTS: DNA methylation levels of IGF2 and AHRR were positively associated with newborn birth weight and Quetelet's index, while DNA methylation levels of HSD11B2 and WNT2 were negatively associated with those fetal growth indicators. In addition, significantly elevated odds of FGR birth were associated with increasing DNA methylation of HSD11B2 and WNT2, and decreasing DNA methylation of IGF2. CONCLUSION: Our findings demonstrated that placental DNA methylation levels of IGF2, AHRR, HSD11B2 and WNT2 were associated with measures of fetal growth.
Authors: Ewka C M Nelissen; Aafke P A van Montfoort; John C M Dumoulin; Johannes L H Evers Journal: Hum Reprod Update Date: 2010-10-19 Impact factor: 15.610
Authors: Christiane A Opitz; Ulrike M Litzenburger; Felix Sahm; Martina Ott; Isabel Tritschler; Saskia Trump; Theresa Schumacher; Leonie Jestaedt; Dieter Schrenk; Michael Weller; Manfred Jugold; Gilles J Guillemin; Christine L Miller; Christian Lutz; Bernhard Radlwimmer; Irina Lehmann; Andreas von Deimling; Wolfgang Wick; Michael Platten Journal: Nature Date: 2011-10-05 Impact factor: 49.962
Authors: Jose C Ferreira; Sanaa Choufani; Daria Grafodatskaya; Darci T Butcher; Chunhua Zhao; David Chitayat; Cheryl Shuman; John Kingdom; Sarah Keating; Rosanna Weksberg Journal: Epigenetics Date: 2011-04-01 Impact factor: 4.528
Authors: Erin L Crowgey; Adam G Marsh; Karyn G Robinson; Stephanie K Yeager; Robert E Akins Journal: BMC Bioinformatics Date: 2018-06-21 Impact factor: 3.169
Authors: Alison Bowman; Karen E Peterson; Dana C Dolinoy; John D Meeker; Brisa N Sánchez; Adriana Mercado-Garcia; Martha M Téllez-Rojo; Jaclyn M Goodrich Journal: Front Public Health Date: 2019-06-19
Authors: Nimesh A Jayasuriya; Alice E Hughes; Ulla Sovio; Emma Cook; D Stephen Charnock-Jones; Gordon C S Smith Journal: J Clin Endocrinol Metab Date: 2019-06-01 Impact factor: 5.958
Authors: Jessica L O'Callaghan; Vicki L Clifton; Peter Prentis; Adam Ewing; Yvette D Miller; Elise S Pelzer Journal: Genes (Basel) Date: 2020-01-10 Impact factor: 4.096
Authors: S E Dwi Putra; C Reichetzeder; A A Hasan; T Slowinski; C Chu; B K Krämer; B Kleuser; B Hocher Journal: Sci Rep Date: 2020-01-22 Impact factor: 4.379