J Yang1, Q Li2, X Yang3, M Li4. 1. Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China. 2. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China. 3. Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China. 4. Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China li.ming@zs-hospital.sh.cn.
Abstract
OBJECTIVE: Prolactin (PRL) is known to aid effector B cells and augment autoimmunity, but the role of PRL in systemic lupus erythematosus (SLE) is not fully elucidated. The aim of this study was to determine the correlation between the serum levels of PRL and autoantibody production in SLE. METHODS: Blood levels of PRL, anti-double-stranded DNA (ds-DNA) antibody, immunoglobulin M (IgM) and immunoglobulin G (IgG) were determined in samples from 30 adult patients with SLE and 25 healthy controls. The relationships between the serum level of PRL and SLE disease activity, as well as the titres of the ds-DNA antibody, IgM and IgG were determined. RESULTS: The serum level of PRL was higher in the SLE patients than in the healthy controls. PRL concentration increased during SLE flares-ups and decreased following disease remission. There was a positive correlation between the PRL concentration and serum levels of IgM, IgG and ds-DNA antibody titre. CONCLUSION: These data suggest that the serum level of PRL was closely related to the antibody production and disease activity of SLE patients. PRL concentration was dramatically reduced upon the remission of disease activity, indicating that PRL levels might be a promising predictor of SLE disease severity.
OBJECTIVE:Prolactin (PRL) is known to aid effector B cells and augment autoimmunity, but the role of PRL in systemic lupus erythematosus (SLE) is not fully elucidated. The aim of this study was to determine the correlation between the serum levels of PRL and autoantibody production in SLE. METHODS: Blood levels of PRL, anti-double-stranded DNA (ds-DNA) antibody, immunoglobulin M (IgM) and immunoglobulin G (IgG) were determined in samples from 30 adult patients with SLE and 25 healthy controls. The relationships between the serum level of PRL and SLE disease activity, as well as the titres of the ds-DNA antibody, IgM and IgG were determined. RESULTS: The serum level of PRL was higher in the SLEpatients than in the healthy controls. PRL concentration increased during SLE flares-ups and decreased following disease remission. There was a positive correlation between the PRL concentration and serum levels of IgM, IgG and ds-DNA antibody titre. CONCLUSION: These data suggest that the serum level of PRL was closely related to the antibody production and disease activity of SLEpatients. PRL concentration was dramatically reduced upon the remission of disease activity, indicating that PRL levels might be a promising predictor of SLE disease severity.
Authors: Luis J Jara; Gabriela Medina; Miguel A Saavedra; Olga Vera-Lastra; Honorio Torres-Aguilar; Carmen Navarro; Monica Vazquez Del Mercado; Luis R Espinoza Journal: Immunol Res Date: 2017-04 Impact factor: 2.829
Authors: Fernanda Nogueira Holanda Ferreira Braga; Marta Maria das Chagas Medeiros; Antonio Brazil Viana Junior; Matheus Eugênio de Sousa Lima; Levi Coelho Maia Barros; Marcelo Ximenes Pontes; Allysson Wosley de Sousa Lima; Paula Frassinetti Castelo Branco Camurça Fernandes Journal: Adv Rheumatol Date: 2022-01-04