Hadi Zarafshan1, Ali Khaleghi1,2, Mohammad Reza Mohammadi1, Mahdi Moeini1, Nastaran Malmir1. 1. a Psychiatry & Psychology Research Center , Tehran University of Medical Sciences , Tehran , Iran. 2. b Department of Biomedical Engineering , Science and Research Branch, Islamic Azad University , Tehran , Iran.
Abstract
OBJECTIVE: The aim of this study was to investigate electroencephalogram (EEG) dynamics using complexity analysis in children with attention-deficit/hyperactivity disorder (ADHD) compared with healthy control children when performing a cognitive task. METHOD: Thirty 7-12-year-old children meeting Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) criteria for ADHD and 30 healthy control children underwent an EEG evaluation during a cognitive task, and Lempel-Ziv complexity (LZC) values were computed. There were no significant differences between ADHD and control groups on age and gender. RESULTS: The mean LZC of the ADHD children was significantly larger than healthy children over the right anterior and right posterior regions during the cognitive performance. In the ADHD group, complexity of the right hemisphere was higher than that of the left hemisphere, but the complexity of the left hemisphere was higher than that of the right hemisphere in the normal group. CONCLUSION: Although fronto-striatal dysfunction is considered conclusive evidence for the pathophysiology of ADHD, our arithmetic mental task has provided evidence of structural and functional changes in the posterior regions and probably cerebellum in ADHD.
OBJECTIVE: The aim of this study was to investigate electroencephalogram (EEG) dynamics using complexity analysis in children with attention-deficit/hyperactivity disorder (ADHD) compared with healthy control children when performing a cognitive task. METHOD: Thirty 7-12-year-old children meeting Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) criteria for ADHD and 30 healthy control children underwent an EEG evaluation during a cognitive task, and Lempel-Ziv complexity (LZC) values were computed. There were no significant differences between ADHD and control groups on age and gender. RESULTS: The mean LZC of the ADHDchildren was significantly larger than healthy children over the right anterior and right posterior regions during the cognitive performance. In the ADHD group, complexity of the right hemisphere was higher than that of the left hemisphere, but the complexity of the left hemisphere was higher than that of the right hemisphere in the normal group. CONCLUSION: Although fronto-striatal dysfunction is considered conclusive evidence for the pathophysiology of ADHD, our arithmetic mental task has provided evidence of structural and functional changes in the posterior regions and probably cerebellum in ADHD.
Authors: Loyda Hernández-Andrade; Ana Cristina Hermosillo-Abundis; Brenda Lesly Betancourt-Navarrete; Diane Ruge; Carlos Trenado; Rafael Lemuz-López; Héctor Juan Pelayo-González; Vicente Arturo López-Cortés; María Del Rosario Bonilla-Sánchez; Marco Antonio García-Flores; Ignacio Méndez-Balbuena Journal: Int J Environ Res Public Health Date: 2022-05-13 Impact factor: 4.614