| Literature DB >> 26678162 |
Chaim Putterman1, Alan Wu2, Anat Reiner-Benaim3, D Scott Batty4, Ignacio Sanz5, Jim Oates6, Keren Jakobi7, Michelle Petri8, Pennina Safer7, Robert Gerwien9, Rachel Sorek7, Yakov Blumenstein7, Irun R Cohen10.
Abstract
We describe here the development, verification and validation of the SLE-key(®) rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP(®) micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.Entities:
Keywords: Autoantibodies; Diagnosis; ICHIP; Microarray; Multivariate classifier; Systemic lupus erythematosus
Mesh：
Substances：
Year: 2015 PMID： 26678162 PMCID： PMC4824168 DOI： 10.1016/j.jim.2015.12.003
Source DB: PubMed Journal: J Immunol Methods ISSN： 0022-1759 Impact factor: 2.303