Anne Samier-Guérin1, Alain Saraux2, Simon Gestin3, Divi Cornec2, Thierry Marhadour4, Valérie Devauchelle-Pensec2, Luc Bressollette3, Michel Nonent1, Sandrine Jousse-Joulin5. 1. Service de radiologie, CHU de la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest, France. 2. Service de rhumatologie, CHU de la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest, France; EA 2216, université Bretagne-Occidentale, BP 824, 29200 Brest, France. 3. Unité de médecine vasculaire, CHU de la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest, France. 4. Service de rhumatologie, CHU de la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest, France. 5. Service de rhumatologie, CHU de la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest, France; Unité de médecine vasculaire, CHU de la Cavale-Blanche, boulevard Tanguy-Prigent, 29609 Brest, France; EA 2216, université Bretagne-Occidentale, BP 824, 29200 Brest, France. Electronic address: sandrine.jousse-joulin@chu-brest.fr.
Abstract
OBJECTIVES: The diagnosis of primary Sjögren's syndrome (pSS) rests on a converging set of clinical and laboratory findings. Salivary-gland ultrasonography (SGUS) was recently shown to assist in the diagnosis and therapeutic monitoring of pSS. Our objective here was to measure salivary-gland elasticity using Acoustic Radiation Force Impulse (ARFI) ultrasonography in patients with pSS and to compare the results to those obtained in healthy controls. METHODS: SGUS with ARFI elastometry was performed in 10 patients with pSS and 15 healthy controls. Ten impulses per gland were used for both submandibular and both parotid glands of each participant. Mean shear wave velocity (SWV) in m/s was compared between the patients and controls using the Mann-Whitney U test. RESULTS: For the parotid glands, mean SWV was significantly higher in the pSS group than in the control group (2.335±0.315 vs 1.785±0.384, respectively; P=0.001). Mean SWV values for the submandibular glands were not significantly different between the patients and controls (1.812±0.308 vs 1.766±0.187, respectively; P=0.892). CONCLUSION: ARFI elastometry may contribute to the diagnosis of pSS, as this noninvasive, fast, and inexpensive investigation can demonstrate abnormal architectural changes in the parotid glands.
OBJECTIVES: The diagnosis of primary Sjögren's syndrome (pSS) rests on a converging set of clinical and laboratory findings. Salivary-gland ultrasonography (SGUS) was recently shown to assist in the diagnosis and therapeutic monitoring of pSS. Our objective here was to measure salivary-gland elasticity using Acoustic Radiation Force Impulse (ARFI) ultrasonography in patients with pSS and to compare the results to those obtained in healthy controls. METHODS: SGUS with ARFI elastometry was performed in 10 patients with pSS and 15 healthy controls. Ten impulses per gland were used for both submandibular and both parotid glands of each participant. Mean shear wave velocity (SWV) in m/s was compared between the patients and controls using the Mann-Whitney U test. RESULTS: For the parotid glands, mean SWV was significantly higher in the pSS group than in the control group (2.335±0.315 vs 1.785±0.384, respectively; P=0.001). Mean SWV values for the submandibular glands were not significantly different between the patients and controls (1.812±0.308 vs 1.766±0.187, respectively; P=0.892). CONCLUSION: ARFI elastometry may contribute to the diagnosis of pSS, as this noninvasive, fast, and inexpensive investigation can demonstrate abnormal architectural changes in the parotid glands.
Authors: Marta Świecka; Łukasz Paluch; Piotr Pietruski; Maria Maślińska; Jakub Zakrzewski; Brygida Kwiatkowska Journal: Rheumatol Int Date: 2022-05-04 Impact factor: 3.580