Literature DB >> 26677788

Prevention of chemotherapy-induced ovarian damage.

Hadassa Roness1, Oren Kashi1, Dror Meirow2.   

Abstract

Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened up new directions for the protection of the ovary from chemotherapy-induced damage. These advances have spurred the investigation of pharmacological agents to prevent ovarian damage at the time of treatment. Prevention of ovarian damage and follicle loss would provide significant advantages over existing fertility preservation techniques. This manuscript reviews new methods for the prevention of chemotherapy-induced ovarian damage, including agents that act on the PI3K/PTEN/Akt follicle activation pathway, apoptotic pathways, the vascular system, and other potential methods of reducing chemotherapy-induced ovotoxicity.
Copyright © 2016. Published by Elsevier Inc.

Entities:  

Keywords:  Fertility preservation; chemotherapy; follicle activation

Mesh：

Substances：

Year:  2015        PMID： 26677788     DOI： 10.1016/j.fertnstert.2015.11.043

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  32 in total

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