Shuangli Mi1, Arne Klungland2,3, Yun-Gui Yang4. 1. Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. 2. Department of Microbiology, Division of Diagnostics and Intervention, Institute of Clinical Medicine, Oslo University Hospital, Rikshospitalet, Oslo, NO-0027, Norway. arne.klungland@medisin.uio.no. 3. Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. arne.klungland@medisin.uio.no. 4. Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.