Cléber de Mesquita Andrade1, Antônia Cláudia Jácome da Câmara2, Daniela Ferreira Nunes3, Paulo Marcos da Matta Guedes4, Wogelsanger Oliveira Pereira5, Egler Chiari3, Rosiane Viana Zuza Diniz1, Lúcia Maria da Cunha Galvão1. 1. Programa de Pós-Graduação em Ciências da Saúde, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. 2. Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. 3. Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 4. Departamento de Microbiologia e Parasitologia, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. 5. Faculdade de Ciências da Saúde, Universidade do Estado do Rio Grande do Norte, Mossoró, Rio Grande do Norte, Brazil.
Abstract
INTRODUCTION: This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS: This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS: The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1% (15/186) and 8.1% (15/186) of the participants, respectively. Heart failure (functional classes I-IV) was detected in 7.5% (14/186) of the participants, and 36.4% (24/66), 30.3% (20/66), 15.2% (10/66), 13.6% (9/66), and 4.5% (3/66) of the patients were at stage A, B1, B2, C, and D, respectively. Dilated cardiomyopathy and electrocardiographic changes were detected in 10.2% (19/186) and 48.1% (91/186) of the participants, respectively. Apical aneurysm was diagnosed in 10.8% (20/186) of the participants, and other changes in the segmental myocardial contractility of the left ventricle were diagnosed in 33.9% (63/186) of the participants. Megaesophagus (groups I-IV) was observed in 7% (13/186) of the participants, megacolon (grades 1-3) was detected in 12.9% (24/186) of the participants, and both organs were affected in 29.2% (7/24) of the megacolon cases. CONCLUSIONS: We detected various clinical forms of Chagas disease (including the digestive form). Our findings indicate that clinical symptoms alone may not be sufficient to exclude or confirm cardiac and/or digestive damage, and the number of patients with symptomatic clinical forms may be underestimated.
INTRODUCTION: This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS: This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS: The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1% (15/186) and 8.1% (15/186) of the participants, respectively. Heart failure (functional classes I-IV) was detected in 7.5% (14/186) of the participants, and 36.4% (24/66), 30.3% (20/66), 15.2% (10/66), 13.6% (9/66), and 4.5% (3/66) of the patients were at stage A, B1, B2, C, and D, respectively. Dilated cardiomyopathy and electrocardiographic changes were detected in 10.2% (19/186) and 48.1% (91/186) of the participants, respectively. Apical aneurysm was diagnosed in 10.8% (20/186) of the participants, and other changes in the segmental myocardial contractility of the left ventricle were diagnosed in 33.9% (63/186) of the participants. Megaesophagus (groups I-IV) was observed in 7% (13/186) of the participants, megacolon (grades 1-3) was detected in 12.9% (24/186) of the participants, and both organs were affected in 29.2% (7/24) of the megacolon cases. CONCLUSIONS: We detected various clinical forms of Chagas disease (including the digestive form). Our findings indicate that clinical symptoms alone may not be sufficient to exclude or confirm cardiac and/or digestive damage, and the number of patients with symptomatic clinical forms may be underestimated.
Authors: Santiago Panesso-Gómez; Paula Pavia; Iván Enrique Rodríguez-Mantilla; Paola Lasso; Luis A Orozco; Adriana Cuellar; Concepción J Puerta; Belén Mendoza de Molano; John M González Journal: Am J Trop Med Hyg Date: 2018-02-01 Impact factor: 2.345
Authors: Nathalie de Sena Pereira; Tamyres Bernadete Dantas Queiroga; Daniela Ferreira Nunes; Cléber de Mesquita Andrade; Manuela Sales Lima Nascimento; Maria Adelaide Do-Valle-Matta; Antônia Cláudia Jácome da Câmara; Lúcia Maria da Cunha Galvão; Paulo Marcos Matta Guedes; Egler Chiari Journal: PLoS Negl Trop Dis Date: 2018-07-25
Authors: George Harisson Felinto Sampaio; Andressa Noronha Barbosa da Silva; Carlos Ramon do Nascimento Brito; Nathan Ravi Medeiros Honorato; Luara Musse de Oliveira; Antônia Claudia Jácome da Câmara; Lúcia Maria da Cunha Galvão Journal: Rev Soc Bras Med Trop Date: 2020-09-11 Impact factor: 1.581
Authors: Nathalie de Sena Pereira; Tamyres Bernadete Dantas Queiroga; Denis Dantas da Silva; Manuela Sales Lima Nascimento; Cléber Mesquita de Andrade; Janeusa Trindade de Souto; Mayra Fernanda Ricci; Rosa Maria Esteves Arantes; Dario Simões Zamboni; Egler Chiari; Antônia Cláudia Jácome da Câmara; Lúcia Maria da Cunha Galvão; Paulo Marcos Matta Guedes Journal: PLoS Negl Trop Dis Date: 2020-09-28