Kannan Rajendran1, Senthil Manikandan2, Lal Devayanivasudevan Nair3, Rajendran Karuthodiyil4, Nikhilan Vijayarajan5, Rajiv Gnanasekar5, Vivian V Kapil5, Azeem S Mohamed5. 1. Associate Professor Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India . 2. Assistant Professor, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India . 3. Assistant Professor, Department of Pediatrics, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India . 4. Professor, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India . 5. Interns, Department of General Medicine, Saveetha Medical College & Hospital, Saveetha University , Thandalam, Chennai, Tamilnadu, India .
Abstract
INTRODUCTION: Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. There have been previous studies to suggest that low serum levels of chromium are associated with poorer glycaemic control. AIM: To study the level of serum chromium in newly diagnosed patients with type 2 diabetes mellitus and its association with glycaemic control. MATERIALS AND METHODS: Serum chromium concentration was determined by using inductively coupled Plasma - Optical Emission Spectophotometry in 42 newly diagnosed type 2 diabetes mellitus patients without any pre-existing complications. They were divided into 2 groups - well controlled (HbA1c ≤7.0%) and uncontrolled groups (HbA1c >7.0%). RESULTS: Mean serum chromium concentration measured in uncontrolled type 2 diabetic patients was significantly lower (0.065 ± 0.03 mcg/L vs 0.103 ± 0.04 mcg/L, p< 0.05). There was a statistically significant inverse linear correlation of the HbA1c values and the serum chromium concentration (r= -0.6514, p < 0.0001). There was also a decrease in chromium levels across both the groups with advancing age and the decrease being significant beyond 40 years of age (p<0.05). CONCLUSION: The results of our study describes the relationship between serum chromium levels and control of type 2 diabetes mellitus. Significant reduction in chromium levels are probable indicators of metabolic response to oxidative stress in patients with type 2 diabetes mellitus. Further large scale studies relating serum chromium and type 2 diabetes mellitus may help to understand more about the exact relationship.
INTRODUCTION:Chromium is an essential micronutrient which is required for the normal functioning of insulin and regulation of blood sugar levels. It acts as a vital antioxidant for maintaining insulin homeostasis. In diabetes mellitus, the free radical production is increased and levels of antioxidants like chromium, vanadium, selenium and manganese are reduced. There have been previous studies to suggest that low serum levels of chromium are associated with poorer glycaemic control. AIM: To study the level of serum chromium in newly diagnosed patients with type 2 diabetes mellitus and its association with glycaemic control. MATERIALS AND METHODS: Serum chromium concentration was determined by using inductively coupled Plasma - Optical Emission Spectophotometry in 42 newly diagnosed type 2 diabetes mellituspatients without any pre-existing complications. They were divided into 2 groups - well controlled (HbA1c ≤7.0%) and uncontrolled groups (HbA1c >7.0%). RESULTS: Mean serum chromium concentration measured in uncontrolled type 2 diabeticpatients was significantly lower (0.065 ± 0.03 mcg/L vs 0.103 ± 0.04 mcg/L, p< 0.05). There was a statistically significant inverse linear correlation of the HbA1c values and the serum chromium concentration (r= -0.6514, p < 0.0001). There was also a decrease in chromium levels across both the groups with advancing age and the decrease being significant beyond 40 years of age (p<0.05). CONCLUSION: The results of our study describes the relationship between serum chromium levels and control of type 2 diabetes mellitus. Significant reduction in chromium levels are probable indicators of metabolic response to oxidative stress in patients with type 2 diabetes mellitus. Further large scale studies relating serum chromium and type 2 diabetes mellitus may help to understand more about the exact relationship.
Authors: Sławomir Lewicki; Robert Zdanowski; Małgorzata Krzyżowska; Aneta Lewicka; Bogdan Dębski; Marcin Niemcewicz; Mariusz Goniewicz Journal: Ann Agric Environ Med Date: 2014 Impact factor: 1.447
Authors: Swapnil Rajpathak; Eric B Rimm; Tricia Li; J Steven Morris; Meir J Stampfer; Walter C Willett; Frank B Hu Journal: Diabetes Care Date: 2004-09 Impact factor: 19.112