| Literature DB >> 26675852 |
Ângela Giovana Batista1, Angélica Simões Ferrari2, Débora Cristina da Cunha2, Juliana Kelly da Silva1, Cinthia Baú Betim Cazarin1, Luiz Claudio Correa3, Marcelo Alexandre Prado1, Luciano Bruno de Carvalho-Silva2, Elizabethe Adriana Esteves4, Mário Roberto Maróstica Júnior5.
Abstract
Copaifera langsdorffii (copaiba) is a Brazilian exotic fruit, poorly studied regarding its bioactive composition. The aim of this study was to determine bioactive compounds, antioxidant and antimutagenic activities of copaiba pulp. The samples were extracted with different solvents in order to analyze polyphenol compounds (Folin Ciocalteau and HPLC-DAD), total flavonoids (reaction with AlCl3) and antioxidant capacity (FRAP, ORAC, DPPH). The copaiba fruit showed high polyphenol content and antioxidant capacity. Phenolic compounds, such as gallic acid, epicatechin gallate, catechin, epicatechin and isoquercitrin, were identified in the copaiba pulp. Despite the antioxidant capacity, the highest dose of copaiba showed no antimutagenic effects in the in vivo study. The dose which showed antimutagenic activity was 100 mg kg(-1).Entities:
Keywords: (+)-Catechin (PubChem CID: 964); (−)-Epicatechin (PubChem CID: 72276); (−)-Epicatechin gallate (PubChem CID: 367141); Antioxidant capacity; Copaiba; Gallic acid; Gallic acid (PubChem CID: 370); Isoquercitrin (PubChem CID: 5280804); Micronuclei
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Year: 2015 PMID： 26675852 DOI： 10.1016/j.foodchem.2015.11.093
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514