OBJECTIVE: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in the development of cervical disease is not well established. This study aimed to determine the association of multiple HPV infections with high-risk cervical lesions (hrCLs). STUDY DESIGN: HPV genotyping was performed on 798 SurePath specimens collected between December 1, 2009, and April 30, 2011. The cases were classified as hrCL (n = 90) or non-hrCL (n = 708) based on cytology diagnoses. The association between hrCL and HPV infection patterns was analyzed. RESULTS: Multiple HPV infections were frequently encountered (38.2%) in the cohort. Increased frequency of hrCLs was associated with a single high-risk HPV (hrHPV) infection. An additive or synergistic effect was not observed for hrCL in multiple HPV infections. The hrCL rates appeared to decrease in various patterns of multiple HPV infections, but the reduction was not statistically significant. CONCLUSIONS: Multiple HPV infections are common with no additive or synergistic effect on the development of hrCL. Conversely, reduced hrCL rates were observed in various patterns of multiple HPV infections compared to their single-genotype infection counterparts, suggestive of possible intergenotypic competition or more effective immune response triggered by multiple infections. Further studies in larger cohorts are needed.
OBJECTIVE: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in the development of cervical disease is not well established. This study aimed to determine the association of multiple HPV infections with high-risk cervical lesions (hrCLs). STUDY DESIGN:HPV genotyping was performed on 798 SurePath specimens collected between December 1, 2009, and April 30, 2011. The cases were classified as hrCL (n = 90) or non-hrCL (n = 708) based on cytology diagnoses. The association between hrCL and HPV infection patterns was analyzed. RESULTS:Multiple HPV infections were frequently encountered (38.2%) in the cohort. Increased frequency of hrCLs was associated with a single high-risk HPV (hrHPV) infection. An additive or synergistic effect was not observed for hrCL in multiple HPV infections. The hrCL rates appeared to decrease in various patterns of multiple HPV infections, but the reduction was not statistically significant. CONCLUSIONS:Multiple HPV infections are common with no additive or synergistic effect on the development of hrCL. Conversely, reduced hrCL rates were observed in various patterns of multiple HPV infections compared to their single-genotype infection counterparts, suggestive of possible intergenotypic competition or more effective immune response triggered by multiple infections. Further studies in larger cohorts are needed.
Authors: Luisa Del Río-Ospina; Sara Cecilia Soto-De León; Milena Camargo; Ricardo Sánchez; Cindy Lizeth Mancilla; Manuel Elkin Patarroyo; Manuel Alfonso Patarroyo Journal: PLoS One Date: 2016-11-15 Impact factor: 3.240
Authors: Cameron Klein; Daniela Gonzalez; Kandali Samwel; Crispin Kahesa; Julius Mwaiselage; Nirosh Aluthge; Samodha Fernando; John T West; Charles Wood; Peter C Angeletti Journal: mBio Date: 2019-02-19 Impact factor: 7.867
Authors: Jane Shen-Gunther; Chiou-Miin Wang; Graham M Poage; Chun-Lin Lin; Luis Perez; Nancy A Banks; Tim Hui-Ming Huang Journal: Clin Epigenetics Date: 2016-09-13 Impact factor: 6.551
Authors: Mariel A Oyervides-Muñoz; Antonio A Pérez-Maya; Celia N Sánchez-Domínguez; Anais Berlanga-Garza; Mauro Antonio-Macedo; Lezmes D Valdéz-Chapa; Ricardo M Cerda-Flores; Victor Trevino; Hugo A Barrera-Saldaña; María L Garza-Rodríguez Journal: Viruses Date: 2020-03-31 Impact factor: 5.048