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Literature DB >> 26672939

Designing Better, Not Just Bigger, Multicenter Critical Care Trials.

Michael O Harhay¹, James A Russell.

Abstract

Entities: Disease Species

Mesh：

Year: 2016 PMID： 26672939 PMCID： PMC4683598 DOI： 10.1097/CCM.0000000000001316

Source DB: PubMed Journal: Crit Care Med ISSN： 0090-3493 Impact factor: 7.598

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References

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7 in total

1. Adaptive designs for confirmatory clinical trials.

Authors: Frank Bretz; Franz Koenig; Werner Brannath; Ekkehard Glimm; Martin Posch
Journal: Stat Med Date: 2009-04-15 Impact factor: 2.373

2. Manners of dying in ICU clinical trials.

Authors: Alexis F Turgeon; Samuel Tétrault; François Lauzier
Journal: Ann Am Thorac Soc Date: 2014-12

3. Mortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect.

Authors: Giovanni Landoni; Marco Comis; Massimiliano Conte; Gabriele Finco; Marta Mucchetti; Gianluca Paternoster; Antonio Pisano; Laura Ruggeri; Gabriele Alvaro; Manuela Angelone; Pier C Bergonzi; Speranza Bocchino; Giovanni Borghi; Tiziana Bove; Giuseppe Buscaglia; Luca Cabrini; Lino Callegher; Fabio Caramelli; Sergio Colombo; Laura Corno; Paolo Del Sarto; Paolo Feltracco; Alessandro Forti; Marco Ganzaroli; Massimiliano Greco; Fabio Guarracino; Rosalba Lembo; Rosetta Lobreglio; Roberta Meroni; Fabrizio Monaco; Mario Musu; Giovanni Pala; Laura Pasin; Marina Pieri; Stefania Pisarra; Giuseppe Ponticelli; Agostino Roasio; Francesco Santini; Simona Silvetti; Andrea Székely; Massimo Zambon; Maria Chiara Zucchetti; Alberto Zangrillo; Rinaldo Bellomo
Journal: Crit Care Med Date: 2015-08 Impact factor: 7.598

4. Outcomes and statistical power in adult critical care randomized trials.

Authors: Michael O Harhay; Jason Wagner; Sarah J Ratcliffe; Rachel S Bronheim; Anand Gopal; Sydney Green; Elizabeth Cooney; Mark E Mikkelsen; Meeta Prasad Kerlin; Dylan S Small; Scott D Halpern
Journal: Am J Respir Crit Care Med Date: 2014-06-15 Impact factor: 21.405

Designing Better, Not Just Bigger, Multicenter Critical Care Trials.

1. Adaptive designs for confirmatory clinical trials.

2. Manners of dying in ICU clinical trials.

3. Mortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect.

4. Outcomes and statistical power in adult critical care randomized trials.

Review 5. Many multicenter trials had few events per center, requiring analysis via random-effects models or GEEs.

6. The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies.

7. Assessing potential sources of clustering in individually randomised trials.