Literature DB >> 26672485

Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection.

Zhiyong Song1, Long Liu2, Xiaoyu Wang3, Yongqiang Deng4, Qinggong Nian4, Guangchuan Wang3, Shunya Zhu4, Xiaofeng Li5, Hangyu Zhou1, Tao Jiang5, Xurong Xu6, Ruikang Tang6, Chengfeng Qin2.   

Abstract

Conventional therapeutic monoclonal antibodies (mAbs) are invalid for intracellular viruses but by using in situ biomineralization treatment, they can be successfully delivered into cells to inhibit intracellular viral replication. This achievement significantly expands the applications of mAbs and provides a new intracellular strategy to control viral infections.

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Year:  2016        PMID: 26672485     DOI: 10.1039/c5cc09252c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway.

Authors:  Jun-Fang Zhang; Hua-Long Xiong; Jia-Li Cao; Shao-Juan Wang; Xue-Ran Guo; Bi-Yun Lin; Ying Zhang; Jing-Hua Zhao; Ying-Bin Wang; Tian-Ying Zhang; Quan Yuan; Jun Zhang; Ning-Shao Xia
Journal:  Theranostics       Date:  2018-01-01       Impact factor: 11.556

Review 2.  Targeted Intracellular Delivery of Antibodies: The State of the Art.

Authors:  Tatiana A Slastnikova; A V Ulasov; A A Rosenkranz; A S Sobolev
Journal:  Front Pharmacol       Date:  2018-10-24       Impact factor: 5.810

  2 in total

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