| Literature DB >> 2667217 |
Abstract
In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.Entities:
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Year: 1989 PMID： 2667217 DOI： 10.1016/0168-9525(89)90054-1
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639