Matthew T McMillan1, John D Christein2, Mark P Callery3, Stephen W Behrman4, Jeffrey A Drebin1, Robert H Hollis2, Tara S Kent3, Benjamin C Miller1, Michael H Sprys1, Ammara A Watkins3, Steven M Strasberg5, Charles M Vollmer6. 1. Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 2. Department of Surgery, University of Alabama School of Medicine, Birmingham, AL. 3. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 4. Department of Surgery, University of Tennessee Health Sciences Center, Memphis, TN. 5. Department of Surgery, Washington University in Saint Louis School of Medicine, St. Louis, MO. 6. Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address: Charles.Vollmer@uphs.upenn.edu.
Abstract
BACKGROUND: Differences in the behavior of postoperative pancreatic fistulas (POPF) have been described after various pancreatic resections. Here, we compare POPFs after pancreatoduodenectomy (PD) and distal pancreatectomy (DP) using the average complication burden (ACB), a quantitative measure of complication burden. METHODS: From 2001 to 2014, 837 DPs and 1,533 PDs were performed by 14 surgeons at 4 institutions. POPFs were categorized by International Study Group on Pancreatic Fistula standards as biochemical (grade A) or clinically relevant (CR-POPF; grades B and C). ACB values were derived from fistula severity scores based on the Modified Accordion Severity Grading. The ACB of POPFs was compared between PD and DP. RESULTS: POPFs were more common after DP compared with PD (34.5 vs 27.2%; P < .001); however, the incidence of any complication was greater after PD (64.9 vs 53.2%; P < .001). When POPFs occurred, they were more likely to be the highest-graded complication after DP compared with PD (65.1 vs 51.6%; P < .001). ACB significantly varied between PDs and DPs for grade C POPFs (0.804 vs 0.611; P < .001). POPFs accounted for 31.2% of the overall complication burden after DP compared with 17.5% of the burden after PD. ACB differed significantly across both institutions and surgeons in terms of POPFs, nonfistulous complications, and overall complications (all P < .05). CONCLUSION: Although POPFs occur less frequently after PD, they are associated with a greater complication burden compared with DP. ACB varies significantly between health care providers, suggesting the need for risk-adjusted comparisons of complication severity. Using ACB to evaluate a distinct morbidity has the potential to aid in assessing the impact of procedure-specific complications.
BACKGROUND: Differences in the behavior of postoperative pancreatic fistulas (POPF) have been described after various pancreatic resections. Here, we compare POPFs after pancreatoduodenectomy (PD) and distal pancreatectomy (DP) using the average complication burden (ACB), a quantitative measure of complication burden. METHODS: From 2001 to 2014, 837 DPs and 1,533 PDs were performed by 14 surgeons at 4 institutions. POPFs were categorized by International Study Group on Pancreatic Fistula standards as biochemical (grade A) or clinically relevant (CR-POPF; grades B and C). ACB values were derived from fistula severity scores based on the Modified Accordion Severity Grading. The ACB of POPFs was compared between PD and DP. RESULTS: POPFs were more common after DP compared with PD (34.5 vs 27.2%; P < .001); however, the incidence of any complication was greater after PD (64.9 vs 53.2%; P < .001). When POPFs occurred, they were more likely to be the highest-graded complication after DP compared with PD (65.1 vs 51.6%; P < .001). ACB significantly varied between PDs and DPs for grade C POPFs (0.804 vs 0.611; P < .001). POPFs accounted for 31.2% of the overall complication burden after DP compared with 17.5% of the burden after PD. ACB differed significantly across both institutions and surgeons in terms of POPFs, nonfistulous complications, and overall complications (all P < .05). CONCLUSION: Although POPFs occur less frequently after PD, they are associated with a greater complication burden compared with DP. ACB varies significantly between health care providers, suggesting the need for risk-adjusted comparisons of complication severity. Using ACB to evaluate a distinct morbidity has the potential to aid in assessing the impact of procedure-specific complications.
Authors: Thomas F Seykora; Laura Maggino; Giuseppe Malleo; Major K Lee; Robert Roses; Roberto Salvia; Claudio Bassi; Charles M Vollmer Journal: J Gastrointest Surg Date: 2018-11-07 Impact factor: 3.452
Authors: James R Howe; Nipun B Merchant; Claudius Conrad; Xavier M Keutgen; Julie Hallet; Jeffrey A Drebin; Rebecca M Minter; Terry C Lairmore; Jennifer F Tseng; Herbert J Zeh; Steven K Libutti; Gagandeep Singh; Jeffrey E Lee; Thomas A Hope; Michelle K Kim; Yusuf Menda; Thorvardur R Halfdanarson; Jennifer A Chan; Rodney F Pommier Journal: Pancreas Date: 2020-01 Impact factor: 3.327
Authors: Jason W Denbo; Morgan L Bruno; Jordan M Cloyd; Laura Prakash; Jeffrey E Lee; Michael Kim; Christopher H Crane; Eugene J Koay; Sunil Krishnan; Prajnan Das; Bruce D Minsky; Gauri Varadhachary; Rachna Shroff; Robert Wolff; Milind Javle; Michael J Overman; David Fogelman; Thomas A Aloia; Jean-Nicolas Vauthey; Jason B Fleming; Matthew H G Katz Journal: J Gastrointest Surg Date: 2016-10-11 Impact factor: 3.452
Authors: Matthew T McMillan; Brett L Ecker; Stephen W Behrman; Mark P Callery; John D Christein; Jeffrey A Drebin; Douglas L Fraker; Tara S Kent; Major K Lee; Robert E Roses; Michael H Sprys; Charles M Vollmer Journal: J Gastrointest Surg Date: 2016-10-11 Impact factor: 3.452
Authors: Brett L Ecker; Matthew T McMillan; Laura Maggino; Valentina Allegrini; Horacio J Asbun; Chad G Ball; Claudio Bassi; Joal D Beane; Stephen W Behrman; Adam C Berger; Mark Bloomston; Mark P Callery; John D Christein; Euan Dickson; Elijah Dixon; Jeffrey A Drebin; Carlos Fernandez-Del Castillo; William E Fisher; Zhi Ven Fong; Ericka Haverick; Robert H Hollis; Michael G House; Steven J Hughes; Nigel B Jamieson; Tara S Kent; Stacy J Kowalsky; John W Kunstman; Giuseppe Malleo; Ronald R Salem; Kevin C Soares; Vicente Valero; Ammara A Watkins; Christopher L Wolfgang; Amer H Zureikat; Charles M Vollmer Journal: J Gastrointest Surg Date: 2017-08-24 Impact factor: 3.452
Authors: Priya M Puri; Ammara A Watkins; Tara S Kent; Laura Maggino; Jenna Gates Jeganathan; Mark P Callery; Jeffrey A Drebin; Charles M Vollmer Journal: J Gastrointest Surg Date: 2017-09-05 Impact factor: 3.452
Authors: Matthew T McMillan; Amer H Zureikat; Melissa E Hogg; Stacy J Kowalsky; Herbert J Zeh; Michael H Sprys; Charles M Vollmer Journal: JAMA Surg Date: 2017-04-01 Impact factor: 14.766