Literature DB >> 26670296

Stroke. Support for IV tPA in ischaemic stroke in elderly people.

Susan W Law1, Steven R Levine1.   

Abstract

In Europe, use of intravenous tissue plasminogen activator (tPA) in patients older than 80 years is discouraged because these patients have been excluded from certain past clinical trials. A new retrospective, observational study shows that tPA can substantially improve functional outcome after ischaemic stroke in patients aged 80–89 years.

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Year:  2015        PMID: 26670296     DOI: 10.1038/nrneurol.2015.231

Source DB:  PubMed          Journal:  Nat Rev Neurol        ISSN: 1759-4758            Impact factor:   42.937


  8 in total

1.  Intravenous thrombolysis for acute cerebral ischaemia in old stroke patients ≥ 80 years of age.

Authors:  Gregoire Boulouis; Frederic Dumont; Charlotte Cordonnier; Marie Bodenant; Didier Leys; Hilde Hénon
Journal:  J Neurol       Date:  2011-12-20       Impact factor: 4.849

2.  Intravenous tissue plasminogen activator and stroke in the elderly.

Authors:  W T Longstreth; Ronit Katz; David L Tirschwell; Mary Cushman; Bruce M Psaty
Journal:  Am J Emerg Med       Date:  2010-03       Impact factor: 2.469

Review 3.  Intravenous thrombolysis in acute ischaemic stroke: a systematic review and meta-analysis to aid decision making in patients over 80 years of age.

Authors:  Pallav Bhatnagar; Devesh Sinha; Richard A Parker; Paul Guyler; Anthony O'Brien
Journal:  J Neurol Neurosurg Psychiatry       Date:  2011-02-03       Impact factor: 10.154

4.  Outcomes of intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older.

Authors:  Farrah J Mateen; Majeed Nasser; Byron R Spencer; William D Freeman; Ashfaq Shuaib; Bart M Demaerschalk; Eelco F M Wijdicks
Journal:  Mayo Clin Proc       Date:  2009-04       Impact factor: 7.616

5.  Intravenous thrombolysis for acute ischaemic stroke in the elderly: data from the Baden-Wuerttemberg stroke registry.

Authors:  B Reuter; C Gumbinger; T Sauer; H Wiethölter; I Bruder; S Rode; P A Ringleb; R Kern; W Hacke; M G Hennerici
Journal:  Eur J Neurol       Date:  2015-10-23       Impact factor: 6.089

6.  The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.

Authors:  Peter Sandercock; Joanna M Wardlaw; Richard I Lindley; Martin Dennis; Geoff Cohen; Gordon Murray; Karen Innes; Graham Venables; Anna Czlonkowska; Adam Kobayashi; Stefano Ricci; Veronica Murray; Eivind Berge; Karsten Bruins Slot; Graeme J Hankey; Manuel Correia; Andre Peeters; Karl Matz; Phillippe Lyrer; Gord Gubitz; Stephen J Phillips; Antonio Arauz
Journal:  Lancet       Date:  2012-05-23       Impact factor: 79.321

Review 7.  Effectiveness of alteplase in the very elderly after acute ischemic stroke.

Authors:  Josef Yayan
Journal:  Clin Interv Aging       Date:  2013-07-24       Impact factor: 4.458

Review 8.  Third International Stroke Trial 3: an update.

Authors:  Antonio Arauz; Eivind Berge; Peter Sandercock
Journal:  Curr Opin Neurol       Date:  2014-02       Impact factor: 5.710

  8 in total

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