Literature DB >> 26669800

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease.

Yohei Shibuya1, Catherine Cy Chang1, Ta-Yuan Chang1.   

Abstract

Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Recent studies show that in a mouse model, blocking ACAT1 provides multiple beneficial effects on AD. Here we review the current evidence that implicates ACAT1 as a therapeutic target for AD. We also discuss the potential usage of various ACAT inhibitors currently available to treat AD.

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Year:  2015        PMID： 26669800      PMCID： PMC4976859          DOI： 10.4155/fmc.15.161

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  130 in total

Review 1.  Alzheimer's disease: strategies for disease modification.

Authors:  Martin Citron
Journal:  Nat Rev Drug Discov       Date:  2010-05       Impact factor: 84.694

2.  A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.

Authors:  Mami Ikenoya; Yasunobu Yoshinaka; Hideyuki Kobayashi; Katsumi Kawamine; Kimiyuki Shibuya; Fumiyasu Sato; Kimio Sawanobori; Takuya Watanabe; Akira Miyazaki
Journal:  Atherosclerosis       Date:  2006-07-03       Impact factor: 5.162

3.  Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines.

Authors:  O Lee; C C Chang; W Lee; T Y Chang
Journal:  J Lipid Res       Date:  1998-08       Impact factor: 5.922

4.  Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.

Authors:  Emily L Willner; Bryan Tow; Kimberly K Buhman; Martha Wilson; David A Sanan; Lawrence L Rudel; Robert V Farese
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-21       Impact factor: 11.205

5.  Autophagosomes form at ER-mitochondria contact sites.

Authors:  Maho Hamasaki; Nobumichi Furuta; Atsushi Matsuda; Akiko Nezu; Akitsugu Yamamoto; Naonobu Fujita; Hiroko Oomori; Takeshi Noda; Tokuko Haraguchi; Yasushi Hiraoka; Atsuo Amano; Tamotsu Yoshimori
Journal:  Nature       Date:  2013-03-03       Impact factor: 49.962

6.  Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

Authors:  C C Chang; H Y Huh; K M Cadigan; T Y Chang
Journal:  J Biol Chem       Date:  1993-10-05       Impact factor: 5.157

7.  Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.

Authors:  Milla Koistinaho; Suizhen Lin; Xin Wu; Michail Esterman; Deanna Koger; Jeffrey Hanson; Richard Higgs; Feng Liu; Seema Malkani; Kelly R Bales; Steven M Paul
Journal:  Nat Med       Date:  2004-06-13       Impact factor: 53.440

8.  Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

Authors:  Jing Zhou; Shi-Hao Tan; Valérie Nicolas; Chantal Bauvy; Nai-Di Yang; Jianbin Zhang; Yuan Xue; Patrice Codogno; Han-Ming Shen
Journal:  Cell Res       Date:  2013-01-22       Impact factor: 25.617

9.  ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

Authors:  Suzanne E Wahrle; Hong Jiang; Maia Parsadanian; Justin Legleiter; Xianlin Han; John D Fryer; Tomasz Kowalewski; David M Holtzman
Journal:  J Biol Chem       Date:  2004-07-21       Impact factor: 5.157

10.  The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

Authors:  David R Riddell; Hua Zhou; Thomas A Comery; Evguenia Kouranova; C Frederick Lo; Helen K Warwick; Robert H Ring; Yolanda Kirksey; Suzan Aschmies; Jane Xu; Katie Kubek; Warren D Hirst; Catherine Gonzales; Yi Chen; Erin Murphy; Sarah Leonard; Dmytro Vasylyev; Aram Oganesian; Robert L Martone; Menelas N Pangalos; Peter H Reinhart; J Steve Jacobsen
Journal:  Mol Cell Neurosci       Date:  2007-01-25       Impact factor: 4.314
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  21 in total

1.  Structural basis for catalysis and substrate specificity of human ACAT1.

Authors:  Hongwu Qian; Xin Zhao; Renhong Yan; Xia Yao; Shuai Gao; Xue Sun; Ximing Du; Hongyuan Yang; Catherine C L Wong; Nieng Yan
Journal:  Nature       Date:  2020-05-13       Impact factor: 49.962

Review 2.  Cellular cholesterol homeostasis and Alzheimer's disease.

Authors:  Ta-Yuan Chang; Yoshio Yamauchi; Mazahir T Hasan; Catherine Chang
Journal:  J Lipid Res       Date:  2017-03-15       Impact factor: 5.922

3.  Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant.

Authors:  Qimin Hai; Brian Ritchey; Peggy Robinet; Alexander M Alzayed; Greg Brubaker; Jinying Zhang; Jonathan D Smith
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-11-02       Impact factor: 8.311

Review 4.  Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise.

Authors:  Fei Yin
Journal:  FEBS J       Date:  2022-01-07       Impact factor: 5.622

5.  Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.

Authors:  Maximillian A Rogers; Catherine C Y Chang; Robert A Maue; Elaina M Melton; Andrew A Peden; William S Garver; Junghoon Lee; Peter Schroen; Mitchell Huang; Ta-Yuan Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-04       Impact factor: 12.779

6.  In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis.

Authors:  Yuyan Zhu; Chih-Yu Chen; Junjie Li; Ji-Xin Cheng; Miran Jang; Kee-Hong Kim
Journal:  J Lipid Res       Date:  2018-03-16       Impact factor: 5.922

7.  Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).

Authors:  Jessica Sarahi Alavez-Rubio; Nancy Martínez-Rodríguez; Jorge Escobedo-de-la-Peña; Osvaldo Garrido-Acosta; Teresa Juárez-Cedillo
Journal:  Mol Neurobiol       Date:  2020-10-14       Impact factor: 5.590

8.  Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors.

Authors:  Dongqing Guo; Ming Lu; Xihan Hu; Jiajia Xu; Guangjing Hu; Ming Zhu; Xiaowei Zhang; Qin Li; Catherine C Y Chang; Tayuan Chang; Baoliang Song; Ying Xiong; Boliang Li
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2016-09-29       Impact factor: 3.848

Review 9.  Intracellular Cholesterol Trafficking and Impact in Neurodegeneration.

Authors:  Fabian Arenas; Carmen Garcia-Ruiz; Jose C Fernandez-Checa
Journal:  Front Mol Neurosci       Date:  2017-11-17       Impact factor: 5.639

10.  The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule.

Authors:  Izumi Maezawa; Bende Zou; Jacopo Di Lucente; William S Cao; Conrado Pascual; Sahani Weerasekara; Man Zhang; Xinmin Simon Xie; Duy H Hua; Lee-Way Jin
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472
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