Rocio Aller1, Olatz Izaola2, Beatriz de la Fuente3, Daniel Antonio De Luis Román2. 1. Center of Investigation of Endocrinology and Nutrition, Medicine School. Dept Gastroenterology and Hepatology.. dadluis@yahoo.es. 2. Center of Investigation of Endocrinology and Nutrition, Medicine School. Dept of Endocrinology and Nutrition. Hospital Clínico Universitario. University of Valladolid, Valladolid, Spain.. dadluis@yahoo.es. 3. Center of Investigation of Endocrinology and Nutrition, Medicine School.. dadluis@yahoo.es.
Abstract
BACKGROUND: clinical data on impact of the Mediterranean diet on the the stage of non alcoholic fatty liver disease are limited and these studies have heterogeneous designs. AIM: we decide to explore any potential associations between adherence to the Mediterranean diet and histological characteristics of patients with NAFLD. METHODS: a sample of 82 patients was analyzed in a cross sectional study. To evaluate the level of adherence to the Mediterranean dietary pattern the 14-Item Mediterranean Diet Assessment Tool was used. RESULTS: thirty five patients (42.7%) had a low grade of steatosis (grade 1 of classification) and 47 patients (57.3%) had a high grade of steatosis (grade 2 and 3). Fifty-six patients (68.3%) had liver steatohepatitis and forty-two patients (51.2%) had liver fibrosis. In the logistic regresion analysis, one unit of the 14-Item Mediterranean Diet Assessment Tool was associated with a lower likehood of having steatohepatitis odds ratio 0.43 (CI:95%: 0.29-0.64) and steatosis 0.42 (CI:95%: 0.26- 0.70). Secondly, one unit of HOMA-IR was associated with higher likehood of having steatosis odds ratio 2.01 (CI:95%: 1.08-3.71) and liver fibrosis 1.38 (CI:95%: 1.10-1.80) . CONCLUSIONS: greater adherence to the Mediterranean diet was associated with lower likelihood of high grade of steatosis and presence of steatohepatitis. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
BACKGROUND: clinical data on impact of the Mediterranean diet on the the stage of non alcoholic fatty liver disease are limited and these studies have heterogeneous designs. AIM: we decide to explore any potential associations between adherence to the Mediterranean diet and histological characteristics of patients with NAFLD. METHODS: a sample of 82 patients was analyzed in a cross sectional study. To evaluate the level of adherence to the Mediterranean dietary pattern the 14-Item Mediterranean Diet Assessment Tool was used. RESULTS: thirty five patients (42.7%) had a low grade of steatosis (grade 1 of classification) and 47 patients (57.3%) had a high grade of steatosis (grade 2 and 3). Fifty-six patients (68.3%) had liver steatohepatitis and forty-two patients (51.2%) had liver fibrosis. In the logistic regresion analysis, one unit of the 14-Item Mediterranean Diet Assessment Tool was associated with a lower likehood of having steatohepatitis odds ratio 0.43 (CI:95%: 0.29-0.64) and steatosis 0.42 (CI:95%: 0.26- 0.70). Secondly, one unit of HOMA-IR was associated with higher likehood of having steatosis odds ratio 2.01 (CI:95%: 1.08-3.71) and liver fibrosis 1.38 (CI:95%: 1.10-1.80) . CONCLUSIONS: greater adherence to the Mediterranean diet was associated with lower likelihood of high grade of steatosis and presence of steatohepatitis. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Mathias Plauth; William Bernal; Srinivasan Dasarathy; Manuela Merli; Lindsay D Plank; Tatjana Schütz; Stephan C Bischoff Journal: Clin Nutr Date: 2019-01-16 Impact factor: 7.324
Authors: Saman Khalatbari-Soltani; Fumiaki Imamura; Soren Brage; Emanuella De Lucia Rolfe; Simon J Griffin; Nicholas J Wareham; Pedro Marques-Vidal; Nita G Forouhi Journal: BMC Med Date: 2019-01-24 Impact factor: 8.775