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Literature DB >> 26667071

Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology.

Abstract

Exosomes are nanosized membrane particles that are secreted by cells that transmit information from cell to cell. The information within exosomes prominently includes their protein and RNA payloads. Exosomal microRNAs in particular can potently and fundamentally alter the transcriptome of recipient cells. Here we summarize what is known about exosome biogenesis, content, and transmission, with a focus on cardiovascular physiology and pathophysiology. We also highlight some of the questions currently under active investigation regarding these extracellular membrane vesicles and their potential in diagnostic and therapeutic applications.

Entities: CellLine Chemical Disease Gene Species

Keywords: cardiovascular disease; extracellular vesicles; intracellular communication; microRNA; regenerative medicine; stem cells

Mesh：

Substances：
MicroRNAs

Year: 2015 PMID： 26667071 PMCID： PMC5425157 DOI： 10.1146/annurev-physiol-021115-104929

Source DB: PubMed Journal: Annu Rev Physiol ISSN： 0066-4278 Impact factor: 19.318

111 in total

1. T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor.

Authors: Liudmila Zakharova; Maria Svetlova; Alla F Fomina
Journal: J Cell Physiol Date: 2007-07 Impact factor: 6.384

2. Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells.

Authors: Marie-Ange Renault; Jérôme Roncalli; Jörn Tongers; Tina Thorne; Ekaterina Klyachko; Sol Misener; Olga V Volpert; Shanu Mehta; Aaron Burg; Corinne Luedemann; Gangjian Qin; Raj Kishore; Douglas W Losordo
Journal: J Mol Cell Cardiol Date: 2010-05-15 Impact factor: 5.000

3. Do plant cells secrete exosomes derived from multivesicular bodies?

Authors: Qianli An; Aart Je van Bel; Ralph Hückelhoven
Journal: Plant Signal Behav Date: 2007-01

4. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

Authors: Ruenn Chai Lai; Fatih Arslan; May May Lee; Newman Siu Kwan Sze; Andre Choo; Tian Sheng Chen; Manuel Salto-Tellez; Leo Timmers; Chuen Neng Lee; Reida Menshawe El Oakley; Gerard Pasterkamp; Dominique P V de Kleijn; Sai Kiang Lim
Journal: Stem Cell Res Date: 2010-01-04 Impact factor: 2.020

5. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.

Authors: Jingyao Mu; Xiaoying Zhuang; Qilong Wang; Hong Jiang; Zhong-Bin Deng; Baomei Wang; Lifeng Zhang; Sham Kakar; Yan Jun; Donald Miller; Huang-Ge Zhang
Journal: Mol Nutr Food Res Date: 2014-05-19 Impact factor: 5.914

6. AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: role for proangiogenic effects and alterations in type 2 diabetics.

Authors: Pavani Mocharla; Sylvie Briand; Giovanna Giannotti; Carola Dörries; Philipp Jakob; Francesco Paneni; Thomas Lüscher; Ulf Landmesser
Journal: Blood Date: 2012-11-08 Impact factor: 22.113

Review 7. Membrane budding and scission by the ESCRT machinery: it's all in the neck.

Authors: James H Hurley; Phyllis I Hanson
Journal: Nat Rev Mol Cell Biol Date: 2010-06-30 Impact factor: 94.444

8. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes.

Authors: Tyson Smyth; Max Kullberg; Noeen Malik; Peter Smith-Jones; Michael W Graner; Thomas J Anchordoquy
Journal: J Control Release Date: 2014-12-16 Impact factor: 9.776

Review 9. Exosomes and cardiac repair after myocardial infarction.

Authors: Susmita Sahoo; Douglas W Losordo
Journal: Circ Res Date: 2014-01-17 Impact factor: 17.367

10. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression.

Authors: Yao Liang Tang; Wuqiang Zhu; Min Cheng; Lijuan Chen; John Zhang; Tao Sun; Raj Kishore; M Ian Phillips; Douglas W Losordo; Gangjian Qin
Journal: Circ Res Date: 2009-04-30 Impact factor: 17.367

116 in total

Review 1. A narrative review of exosomes in vascular calcification.

Authors: Zheng Qin; Ruoxi Liao; Yuqin Xiong; Luojia Jiang; Jiameng Li; Liya Wang; Mei Han; Si Sun; Jiwen Geng; Qinbo Yang; Zhuyun Zhang; Yupei Li; Heyue Du; Baihai Su
Journal: Ann Transl Med Date: 2021-04

Review 2. Tiny Shuttles for Information Transfer: Exosomes in Cardiac Health and Disease.

Authors: Raj Kishore; Venkata Naga Srikanth Garikipati; Anna Gumpert
Journal: J Cardiovasc Transl Res Date: 2016-02-24 Impact factor: 4.132

3. A mechanistic roadmap for the clinical application of cardiac cell therapies.

Authors: Eduardo Marbán
Journal: Nat Biomed Eng Date: 2018-06-11 Impact factor: 25.671

4. Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice.

Authors: Russell G Rogers; Mario Fournier; Lizbeth Sanchez; Ahmed G Ibrahim; Mark A Aminzadeh; Michael I Lewis; Eduardo Marbán
Journal: JCI Insight Date: 2019-04-04

5. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium.

Authors: Progyaparamita Saha; Sudhish Sharma; Laxminarayana Korutla; Srinivasa Raju Datla; Farnaz Shoja-Taheri; Rachana Mishra; Grace E Bigham; Malini Sarkar; David Morales; Gregory Bittle; Muthukumar Gunasekaran; Chetan Ambastha; Mir Yasir Arfat; Deqiang Li; Andreas Habertheuer; Robert Hu; Manu O Platt; Peixin Yang; Michael E Davis; Prashanth Vallabhajosyula; Sunjay Kaushal
Journal: Sci Transl Med Date: 2019-05-22 Impact factor: 17.956

Review 6. Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide.

Authors: Tomoko Ichiki; Nina Dzhoyashvili; John C Burnett
Journal: Int J Cardiol Date: 2018-06-03 Impact factor: 4.164