| Literature DB >> 26666606 |
Hisao Imai1, Nozomi Matsumura, Yuichi Yamazaki, Yuki Kanayama, Tomomi Masuda, Tomohito Kuwako, Yosuke Kamide, Taku Tomizawa, Shunichi Matsumoto, Takeki Mitsui, Kyoichi Kaira, Akihiro Ono, Yasuhiko Koga, Nobuyuki Shibusawa, Noriaki Sunaga, Takeshi Hisada, Hideaki Yokoo, Masanobu Yamada.
Abstract
We describe the case of an 85-year-old man diagnosed with chronic myelomonocytic leukemia whose disease was treated with hydroxyurea for 3 months. He developed respiratory symptoms that were extensively investigated. Despite the intensive treatment, he died of respiratory failure eleven days later. An autopsy revealed diffuse interstitial inflammation of both lungs consistent with drug-induced inflammation. A drug lymphocyte stimulation test was positive for hydroxyurea. Taken together these findings demonstrated that severe interstitial pneumonitis was induced by this drug. Physicians using hydroxyurea must be aware of its potentially life-threatening pulmonary toxicity.Entities:
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Year: 2015 PMID： 26666606 DOI： 10.2169/internalmedicine.54.5069
Source DB: PubMed Journal: Intern Med ISSN： 0918-2918 Impact factor: 1.271