| Literature DB >> 26666401 |
Bart van den Munckhof1, Evelien E de Vries1, Kees P J Braun1, H Myrthe Boss1, Michèl A Willemsen2, Annet van Royen-Kerkhof3, Wilco de Jager3, Floor E Jansen1.
Abstract
We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy. Wiley Periodicals, Inc.Entities:
Keywords: CSWS; Continuous spikes and waves during sleep; Cytokines; ESES; Electrical status epilepticus during sleep; Landau-Kleffner syndrome
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Year: 2015 PMID： 26666401 DOI： 10.1111/epi.13274
Source DB: PubMed Journal: Epilepsia ISSN： 0013-9580 Impact factor: 5.864